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Development and characterization of CR101-ADC, a fully-human anti-claudin18.2 monoclonal antibody-drug conjugate
Miao Zhang, Haibin Yuan, Xian Li, Jianan Yin, Fei Qi, Junjie Chen, Jiatao Zhou, Xiaolong Wang, Shuping Zhang, Ario De Marco
Izvirni znanstveni članek
Oznake: claudin 18.2;antibody-drug conjugate;tumor therapy;
Claudin18.2 (CLDN18.2) is a stomach-specific tight junction protein aberrantly exposed in multiple cancers, particularly gastric and pancreatic malignancies, making it an attractive therapeutic target. Here, we developed CR101-ADC, a novel antibody-drug conjugate (ADC) constructed from a fully human ...
Leto: 2026 Vir: Univerza v Novi Gorici (UNG)
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