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Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases
Feizhi Song, Valerija Kovač, Behnam Mohammadi, Jessica L. Littau, Franka Scharfenberg, Andreu Matamoros Angles, Ilaria Vanni, Mohsin Shafiq, Leonor Orge, Giovanna Galliciotti, Katrina Pretnar-Hartman, Maja Černilec, Katrina Pretnar-Hartman, Lojze Šmid, Mara Bresjanac, Vladka Čurin-Šerbec
Izvirni znanstveni članek
Oznake: Alzheimer’s disease;dementia;extracellular vesicles;neuroprotection;prions;proteolytic processing;
Proteolytic cell surface release ('shedding') of the prion protein (PrP), a broadly expressed GPI-anchored glycoprotein, by the metalloprotease ADAM10 impacts on neurodegenerative and other diseases in animal and in vitro models. Recent studies employing the latter also suggest shed PrP (sPrP) to be ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
An Archaeology of Affect: Reading, History and Gender
Karin Littau
Ni določena
Oznake: history of reading; reading habits; women writers; literary experience; affective reading; Emma Bovary
Literary history is filled with stories of reading as a deeply affective experience. Why does our own age deem such reactions trivial? And why is affective reading almost exclusively now associated with women readers?
Leto: 2017 Vir: ZRC SAZU
Št. zadetkov: 2
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