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Št. zadetkov: 5
LEOPARD
Siyu Han, Jerzy Adamski, Rui Wang-Sattler
Izvirni znanstveni članek
Oznake: multi-timepoint omics data;representation;temporal knowledge transfer;
Longitudinal multi-view omics data offer unique insights into the temporal dynamics of individual-level physiology, which provides opportunities to advance personalized healthcare. However, the common occurrence of incomplete views makes extrapolation tasks difficult, and there is a lack of tailored ...
Leto: 2025 Vir: Medicinska fakulteta (UL MF)
Precision integrated identification of predictive first-trimester metabolomics signatures for early detection of gestational diabetes mellitus
Sapna Sharma, Yalamanchili Venkata Subrahmanyam, Payal Gupta, Sangeetha Vadivel, Mohan Deepa, Ansh Tandon, Jerzy Adamski
Izvirni znanstveni članek
Oznake: first trimester;gestational diabetes mellitus;indian women;mass spectrometry;metabolomics;prediction;
Background and aim: Gestational diabetes mellitus (GDM), a common pregnancy-related metabolic disorder, often goes undiagnosed until the second trimester, limiting early intervention opportunities. Given the higher prevalence of GDM in India, there is a critical need to investigate metabolomic bioma ...
Leto: 2025 Vir: Medicinska fakulteta (UL MF)
ǂThe ǂdynamics of the gut microbiota in prediabetes during a four-year follow-up among European patients-an IMI-DIRECT prospective study
Liwei Lyu, Yong Fang, Josef Korbinian Vogt, Marc Clos-Garcia, Amelie Bonnefond, Helle Krogh Pedersen, Jerzy Adamski
Izvirni znanstveni članek
Oznake: gut bacterial genetics;gut bacterial microbiota;gut viral microbiota;insulin sensitivity;long-term dynamics;metabolism;microbial functional pathways;prediabetes;
Background: Previous case-control studies have reported aberrations of the gut microbiota in individuals with prediabetes. The primary objective of the present study was to explore the dynamics of the gut microbiota of individuals with prediabetes over 4 years with a secondary aim of relating microb ...
Leto: 2025 Vir: Medicinska fakulteta (UL MF)
Pantothenate kinase 4 controls skeletal muscle substrate metabolism
Adriana Miranda-Cervantes, Adriana Miranda-Cervantes, Andreas M. Fritzen, Steffen H. Raun, Ondřej Hodek, Lisbeth L. V. Møller, Kornelia Johann, Jerzy Adamski
Izvirni znanstveni članek
Oznake: pantothenate kinase 4;metabolism;substrate;skeletal muscle;
Metabolic flexibility in skeletal muscle is essential for maintaining healthy glucose and lipid metabolism, and its dysfunction is closely linked to metabolic diseases. Exercise enhances metabolic flexibility, making it an important tool for discovering mechanisms that promote metabolic health. Here ...
Leto: 2025 Vir: Medicinska fakulteta (UL MF)
Individual bioenergetic capacity as a potential source of resilience to Alzheimer's disease
Matthias Arnold, Mustafa Buyukozkan, P. Murali Doraiswamy, Kwangsik Nho, Tong Wu, Vilmundur Gudnason, Lenore J. Launer, Rui Wang-Sattler, Jerzy Adamski, Philip L. De Jager
Izvirni znanstveni članek
Oznake: bioenergetic capacity;resilience;Alzheimer's disease;bioenergetska zmogljivost;odpornost;Alzheimerjeva bolezen;
Impaired glucose uptake in the brain is one of the earliest presymptomatic manifestations of Alzheimer's disease (AD). The absence of symptoms for extended periods of time suggests that compensatory metabolic mechanisms can provide resilience. Here, we introduce the concept of a systemic 'bioenerget ...
Leto: 2025 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 5
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