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Št. zadetkov: 4
Secreted phospholipases A[sub]2 - not just enzymes
Jernej Šribar, Igor Križaj
Pregledni znanstveni članek
Oznake: biokemija;molekularna biologija;kačji strupi;fosfolipaze;receptorji;
Secreted phospholipases Asub2 - not just enzymes
Leto: 2011 Vir: dLib.si Digitalna knjižnica Slovenije
Anti-vimentin, anti-TUFM, anti-NAP1L1 and anti-DPYSL2 nanobodies display cytotoxic effect and reduce glioblastoma cell migration
Alja Zottel, Ivana Jovchevska, Neja Zupanec, Jernej Mlakar, Jernej Šribar, Igor Križaj, Marija Skoblar Vidmar, Radovan Komel
Izvirni znanstveni članek
Oznake: glioblastoma;stem cells;nanobodies;cell migration;citotoxicity;vimentin;DPYSL2;NAP1L1;TUFM;
Background: Glioblastoma is a particularly common and very aggressive primary brain tumour. One of the main causes of therapy failure is the presence of glioblastoma stem cells that are resistant to chemotherapy and radiotherapy, and that have the potential to form new tumours. This study focuses on ...
Leto: 2020 Vir: Medicinska fakulteta (UL MF)
Comparative electrophysiological characterization of ammodytoxin A, a β-neurotoxin from the nose-horned viper venom, and its enzymatically inactive mutant
Monika C. Žužek, Adrijan Ivanušec, Julija Herman, Jernej Šribar, Adrijana Leonardi, Robert Frangež, Igor Križaj
Izvirni znanstveni članek
Oznake: kačji strup;encimska aktivnost;snake venom;ammodytoxin;secreted phospholipase A2;anzymatic activity;cytochrome c oxidase;ß-neurotoxicity;
Presynaptic- or β-neurotoxicity of secreted phospholipases A2 (sPLA2) is a complex process. For full expression of β-neurotoxicity, the enzymatic activity of the toxin is essential. However, it has been shown that not all toxic effects of a β-neurotoxin depend on its enzymatic activity, for example, ...
Leto: 2024 Vir: Veterinarska fakulteta (UL VF)
In vitro functional validation of an anti-FREM2 nanobody for glioblastoma cell targeting
Gloria Krapež, Neja Zupanec, Alja Zottel, Mojca Katrašnik, Ana Kump, Jernej Šribar, Igor Križaj, Jure Stojan, Rok Romih, Gregor Bajc, Matej Butala, Serge Muyldermans, Ivana Jovchevska, Ivana Jovchevska
Izvirni znanstveni članek
Oznake: brain cancer;membrane-bound protein;cytotoxicity;molecular tool;subcellular localization;
Background/Objectives: Glioblastomas are the most common brain malignancies. Despite the implementation of multimodal therapy, patient life expectancy after diagnosis is barely 12 to 18 months. Glioblastomas are highly heterogeneous at the genetic and epigenetic level and comprise multiple different ...
Leto: 2025 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 4
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