Št. zadetkov: 12
Izvirni znanstveni članek
Oznake:
rak trebuha;stanje prehranjenosti;telesna sestava;abdominal cancer;nutritional status;body composition;
Background. The significance of nutritional care in the management of cancer, particularly in the surgical treatment of abdominal cancer, is increasingly acknowledged. Body composition analysis, such as the Bioelectric impedance assay (BIA), and functional tests, e.g., handgrip strength, are used wh ...
Leto:
2023
Vir:
Onkološki inštitut Ljubljana (OI)
Pregledni znanstveni članek
Oznake:
diabetes mellitus;erectile dysfunction;genetic polymorphisms;
Introduction Erectile dysfunction (ED) is a highly prevalent complication of diabetes mellitus (DM), significantly impairing quality of life and psychosocial well-being. The prevalence of ED is estimated to be over 3.5 times higher in men with diabetes mellitus compared to those without. The aetiolo ...
Leto:
2025
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
polymorphism;type 2 diabetes;treatment response;
We investigated the impact of genetic polymorphisms in the GLP1R and SLC5A2 genes on the response to treatment with glucagon-like peptide-1 receptor (GLP-1R) agonists and sodium-glucose co-transporter-2 (SLGT2) inhibitors in patients with type 2 diabetes mellitus (T2DM) in everyday clinical practice ...
Leto:
2025
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Pregledni znanstveni članek
Oznake:
SGLT2 inhibitorji;kardiovaskularna varnost;nefrologija;genetski polimorfizem;
SGLT2 (sodium-glucose cotransporter 2) inhibitors are a new class of antihyperglycaemic drugs that act on the proximal tubules of the kidney. They have shown efficacy in the management of diabetes mellitus type 2 and their cardiovascular and renal safety have been extensively investigated and confir ...
Leto:
2021
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
akutna ishemija;arterijski embolizem;etiologija;diagnostični pristop;
Superior mesenteric artery embolisation is the most common cause of acute mesenteric ischaemia. Superior mesenteric artery embolisation can be caused by various cardiac diseases (myocardial ischaemia or infarction, atrial tachyarrhythmias, endocarditis, cardiomyopathies, ventricular aneurysms and va ...
Leto:
2021
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
genetika;debelost;patogeneza;terapije;CRISPR/Cas9;dual therapy;energy homeostasis;gene therapy;gut–brain axis;microbiota;personalized medicine;
Obesity is a chronic metabolic disease characterized by disturbances in energy homeostasis, leading to excessive fat accumulation. The pathogenesis of the disease is shaped by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors. These contributors affect ...
Leto:
2025
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
diabetes mellitus tipa 2;debelost;agonisti receptorjev GLP-1;type 2 diabetes mellitus;obesity;GLP‐1 receptor agonists;
Glucagon-like peptide-1 (GLP-1) receptor agonists are a new class of antihyperglycemic drugs that enhance appropriate pancreatic β-cell secretion, pancreatic α-cell (glucagon) suppression, decrease liver glucose production, increase satiety through their action on the central nervous system, slow ga ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Magistrsko delo
Oznake:
sladkorna bolezen tipa 2;oksidativni stres;antihiperglikemiki;NRF2;KEAP1;
Zdravljenje SBT2 običajno vključuje spremembe življenjskega sloga, kot so ustrezna prehrana in povečanje telesne dejavnosti. Kljub nefarmakološkim ukrepom, spremembe življenjskega sloga pogosto ne zadostujejo za učinkovito obvladovanje bolezni. V mnogih primerih je zato potrebna uporaba antihipergli ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)
Magistrsko delo
Oznake:
sladkorna bolezen tipa 2;BDNF;rs6265;rs28722151;rs11030101;pozni zapleti;
Sladkorna bolezen predstavlja resen javnozdravstveni izziv, ki močno vpliva na kakovost življenja bolnikov s sladkorno boleznijo tipa 2 (SBT2). Kronična hiperglikemija, inzulinska rezistenca in nepravilno delovanje β-celic trebušne slinavke vodijo do oksidativnega stresa, ateroskleroze in poznih zap ...
Leto:
2025
Vir:
Medicinska fakulteta (UL MF)
Magistrsko delo
Oznake:
sladkorna bolezen tipa 2;dolžina telomerov;dislipidemija;vnetje;polimorfizmi provnetnih genov;
Sladkorna bolezen tipa 2 je metabolična in vnetna bolezen, katere pojavnost v zadnjih letih izrazito narašča. Zanjo je poleg hiperglikemije značilen tudi pojav dislipidemije. Slednja v telesu povečuje vnetno stanje ter oksidativni stres. Na to kako buren bo vnetni odziv, vpliva tudi izražanje provne ...
Leto:
2020
Vir:
Fakulteta za farmacijo (UL FFA)