Št. zadetkov: 13
Izvirni znanstveni članek
Oznake:
DFA Alpha 1;atrial fibrillation;coronary artery bypass grafting;heart rate variability;
Background and Objectives: Postoperative atrial fibrillation (AF) is a frequent complication after coronary artery bypass grafting (CABG), and is particularly associated with poor outcomes. Heart rate variability (HRV), a non-invasive marker of autonomic function, has been proposed as a tool to pred ...
Leto:
2025
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Izvirni znanstveni članek
Oznake:
anxiety;depression;cardiac rehabilitation;coronary artery disease;myocardial infarction;pulse-wave velocity;endothelial dysfunction;
Background and aims: Coronary artery disease (CAD) is a leading cause of mortality. Depression and anxiety are common in CAD patients and negatively affect quality of life, physical functioning, and adherence to cardiac rehabilitation (CR) programs. This study aimed to identify possible associations ...
Leto:
2025
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Pregledni znanstveni članek
Oznake:
heart failure;left ventricular assist device;heparin-induced thrombocytopenia;argatroban;anticoagulation;heart transplantation;cardiac surgery;
This review provides an in-depth analysis of argatroban as an alternative anticoagulant in cardiac surgery, with a focus on its use in patients with heparin-induced thrombocytopenia (HIT). We examine argatroban's pharmacokinetics and dosing regimens and the challenges associated with cosnventional m ...
Leto:
2025
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Jan Kafol,
Mia Becker,
Barbara Čugalj Kern,
Jaka Šikonja,
Matej Mlinarič,
Katarina Sedej,
Matej Kafol,
Ana Drole Torkar,
Jernej Kovač,
Tadej Battelino,
Urh Grošelj
Izvirni znanstveni članek
Oznake:
sex differences;prepubertal children;total cholesterol;low-density lipoprotein cholesterol;familial hypercholesterolemia;
Background and aims: Sex differences in cholesterol levels are well documented in adults and adolescents, but limited data exist for prepubertal children. This study aimed to evaluate innate sex differences in total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels among prepub ...
Leto:
2025
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Jan Kafol,
Zlatko Fras,
Marko Novaković,
Laurence S. Sperling,
Matija Cevc,
Barbara Krevel,
Lenart Kafol,
Anamarija Kelenc,
Klarisa Kepic,
Katarina Vrbinc,
Miha Švarc,
Urh Grošelj,
Borut Jug
Izvirni znanstveni članek
Oznake:
zaviralci PCSK9;monoklonska protitelesa;siRNA;študije iz resničnega sveta;zdravilo inclisiran;zdravilo evolokumab;zdravilo alirokumab;LDL-C;intoleranca na statine;kardiovaskularni učinki;PCSK9 inhibitors;monoclonal antibodies;real-world study;inclisiran;evolocumab;alirocumab;statin intolerance;cardiovascular outcomes;
Background and Aims: Randomized trials showed efficacious lipid-lowering with PCSK9 inhibitors (PCSK9i), but real-world treatment is often limited by statin-associated side effects (SASE). We quantified the effectiveness, safety and cardiovascular outcomes of alirocumab, evolocumab and inclisiran in ...
Leto:
2026
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Jaka Šikonja,
Kaja Kobale,
Jan Kafol,
Barbara Čugalj Kern,
Matej Mlinarič,
Ana Drole Torkar,
Jernej Kovač,
Matija Cevc,
Zlatko Fras,
Tadej Battelino,
Urh Grošelj
Izvirni znanstveni članek
Oznake:
child-parent screening;cascade screening;familial hypercholesterolemia;cardiovascular disease;Slovenia;
Background and aims: Cascade familial hypercholesterolemia (FH) screening of parents could reduce the burden cardiovascular disease (CVD) in relatives of index cases by enabling timely diagnosis of FH. Here, we present the positive outcomes of the pilot child-parent cascade screening program in Slov ...
Leto:
2025
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Urh Grošelj,
Jan Kafol,
Neža Molk,
Katarina Sedej,
Matej Mlinarič,
Jaka Šikonja,
Urša Šuštar,
Barbara Čugalj Kern,
Jernej Kovač,
Tadej Battelino,
Maruša Debeljak,
Maruša Debeljak
Izvirni znanstveni članek
Oznake:
APOB;children;hypocholesterolemia;next-generation sequencing;prevalence;
Background and aims: In contrast to extensively studied hypercholesterolemia, knowledge of hypocholesterolemia is limited. This study aims to assess the prevalence, clinical characteristics, and genetics of children and adolescents with hypocholesterolemia. Methods: This national prospective cross-s ...
Leto:
2025
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Quratul Ain,
Jaka Šikonja,
Fouzia Sadiq,
Saeed Shafi,
Jan Kafol,
Tevž Gorjanc,
Urša Šuštar,
Jernej Kovač,
Mohammad Iqbal Khan,
Muhammad Ajmal,
Urh Grošelj,
Urh Grošelj
Izvirni znanstveni članek
Oznake:
cardiovascular disease;cascade screening;consanguineous;familial hypercholesterolemia;homozygous;
Background and aims: Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated low-density lipoprotein cholesterol (LDL-C) levels from birth, significantly increasing the risk of premature cardiac events and mortality. In Pakistan, despite the potential burden of FH, compreh ...
Leto:
2025
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Urh Grošelj,
Jan Kafol,
Jaka Šikonja,
Matej Mlinarič,
Robert Šket,
Žiga Iztok Remec,
Jernej Kovač,
Ana Drole Torkar,
Jasna Šuput,
Barbka Repič-Lampret,
Tadej Battelino,
Primož Kotnik
Izvirni znanstveni članek
Oznake:
insulin resistance;oral glucose tolerance test;OGTT;metabolic complications;screening;children;adolescents;obesity;
Background and aims: Early detection of insulin resistance (IR) and obesity-related complications is crucial for preventing type 2 diabetes. This study aimed to identify dynamic metabolic biomarkers for more precise early detection of IR and metabolic abnormalities. Methods: This cross-sectional coh ...
Leto:
2025
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Jan Kafol,
Jaka Šikonja,
Matej Mlinarič,
Barbara Čugalj Kern,
Mihaela Pricop-Jeckstadt,
Ana Drole Torkar,
Tevž Gorjanc,
Andraž Petek,
Andreja Lakner,
Jernej Kovač,
Tadej Battelino,
Urh Grošelj,
Urh Grošelj
Izvirni znanstveni članek
Oznake:
TSH;low-density lipoprotein cholesterol;familial hypercholesterolemia;LDLR;APOB;subclinical hypothyroidism;
Background and aims Thyroid hormones regulate lipoprotein metabolism—primarily by up-regulating the LDL receptor. Whether TSH relates to LDL-C in hypercholesterolemic children, and whether this depends on familial hypercholesterolemia (FH) status or the underlying defective gene, is uncertain. We ev ...
Leto:
2026
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije