Št. zadetkov: 19
Pregledni znanstveni članek
Oznake:
atherosclerosis;inflammation;residual inflammatory risk;obesity;glucagon-like peptide-1 receptor agonists;semaglutide;tirzepatide;incretin-based therapy;cardiovascular prevention;adipose tissue inflammation;
Cardiovascular disease remains a leading cause of mortality despite major advances in lipid lowering and risk-factor control, highlighting the importance of residual cardiovascular risk. Inflammation is a central driver of atherosclerosis, while obesity promotes chronic low-grade inflammation, adipo ...
Leto:
2026
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Izvirni znanstveni članek
Oznake:
transvenous lead extraction;cardiovascular implantable electronic devices;SAFeTY score;risk stratification;mechanical rotational sheath;
Background/Objectives: The increasing use of cardiovascular implantable electronic devices has increased the need for transvenous lead extraction (TLE), which carries a relevant complication risk. The SAFeTY score was developed to predict procedure-related major complications. We evaluated TLE outco ...
Leto:
2026
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Izvirni znanstveni članek
Oznake:
juvenile-onset Huntington disease;epilepsy;HTT CAG repeat expansion;basal ganglia;systematic review;seizures;
Background: Juvenile-onset Huntington disease (JoHD) is a rare form of Huntington disease characterized by symptom onset at or before 20 years of age. Early manifestations are often non-choreic and may be attributed to developmental, psychiatric, movement, metabolic, or epileptic disorders. We descr ...
Leto:
2026
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Izvirni znanstveni članek
Oznake:
DFA Alpha 1;atrial fibrillation;coronary artery bypass grafting;heart rate variability;
Background and Objectives: Postoperative atrial fibrillation (AF) is a frequent complication after coronary artery bypass grafting (CABG), and is particularly associated with poor outcomes. Heart rate variability (HRV), a non-invasive marker of autonomic function, has been proposed as a tool to pred ...
Leto:
2025
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Izvirni znanstveni članek
Oznake:
cardiac rehabilitation;coronary artery disease;exercise training;water-based (aquatic) exercise;
Cardiac rehabilitation (CR) plays a crucial role in managing patients who have undergone coronary intervention (CI) following acute myocardial infarction. While water-based exercise is gaining recognition as an exercise modality in this patient population, its impact on the subgroup of older adults ...
Leto:
2024
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Izvirni znanstveni članek
Oznake:
anxiety;depression;cardiac rehabilitation;coronary artery disease;myocardial infarction;pulse-wave velocity;endothelial dysfunction;
Background and aims: Coronary artery disease (CAD) is a leading cause of mortality. Depression and anxiety are common in CAD patients and negatively affect quality of life, physical functioning, and adherence to cardiac rehabilitation (CR) programs. This study aimed to identify possible associations ...
Leto:
2025
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Pregledni znanstveni članek
Oznake:
heart failure;left ventricular assist device;heparin-induced thrombocytopenia;argatroban;anticoagulation;heart transplantation;cardiac surgery;
This review provides an in-depth analysis of argatroban as an alternative anticoagulant in cardiac surgery, with a focus on its use in patients with heparin-induced thrombocytopenia (HIT). We examine argatroban's pharmacokinetics and dosing regimens and the challenges associated with cosnventional m ...
Leto:
2025
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Jan Kafol,
Mia Becker,
Barbara Čugalj Kern,
Jaka Šikonja,
Matej Mlinarič,
Katarina Sedej,
Matej Kafol,
Ana Drole Torkar,
Jernej Kovač,
Tadej Battelino,
Urh Grošelj
Izvirni znanstveni članek
Oznake:
sex differences;prepubertal children;total cholesterol;low-density lipoprotein cholesterol;familial hypercholesterolemia;
Background and aims: Sex differences in cholesterol levels are well documented in adults and adolescents, but limited data exist for prepubertal children. This study aimed to evaluate innate sex differences in total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels among prepub ...
Leto:
2025
Vir:
Medicinska fakulteta (UL MF)
Jan Kafol,
Zlatko Fras,
Marko Novaković,
Laurence S. Sperling,
Matija Cevc,
Barbara Krevel,
Lenart Kafol,
Anamarija Kelenc,
Klarisa Kepic,
Katarina Vrbinc,
Miha Švarc,
Urh Grošelj,
Borut Jug
Izvirni znanstveni članek
Oznake:
zaviralci PCSK9;monoklonska protitelesa;siRNA;študije iz resničnega sveta;zdravilo inclisiran;zdravilo evolokumab;zdravilo alirokumab;LDL-C;intoleranca na statine;kardiovaskularni učinki;PCSK9 inhibitors;monoclonal antibodies;real-world study;inclisiran;evolocumab;alirocumab;statin intolerance;cardiovascular outcomes;
Background and Aims: Randomized trials showed efficacious lipid-lowering with PCSK9 inhibitors (PCSK9i), but real-world treatment is often limited by statin-associated side effects (SASE). We quantified the effectiveness, safety and cardiovascular outcomes of alirocumab, evolocumab and inclisiran in ...
Leto:
2026
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Urh Grošelj,
Jan Kafol,
Neža Molk,
Katarina Sedej,
Matej Mlinarič,
Jaka Šikonja,
Urša Šuštar,
Barbara Čugalj Kern,
Jernej Kovač,
Tadej Battelino,
Maruša Debeljak,
Maruša Debeljak
Izvirni znanstveni članek
Oznake:
APOB;children;hypocholesterolemia;next-generation sequencing;prevalence;
Background and aims: In contrast to extensively studied hypercholesterolemia, knowledge of hypocholesterolemia is limited. This study aims to assess the prevalence, clinical characteristics, and genetics of children and adolescents with hypocholesterolemia. Methods: This national prospective cross-s ...
Leto:
2025
Vir:
Repozitorij Univerze v Ljubljani (RUL)