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Št. zadetkov: 6
Conformational propensities of a DNA hairpin with a stem sequence from the c-MYC promoter
Arees Garabet, Iztok Prislan, Nataša Poklar Ulrih, James W. Wells, Tigran V. Chalikian
Izvirni znanstveni članek
Oznake: biofizikalna kemija;G-kvadrupleksi;termodinamika;DNA;G-quadruplex;i-motif;hairpin duplex;conformational states;circular dichroism;thermodynamics;biophysical chemistry;
G-quadruplexes and i-motifs are four-stranded non-canonical structures of DNA. They exist in the cell, where they are implicated in the conformational regulation of cellular events, such as transcription, translation, DNA replication, telomere homeostasis, and genomic instability. Formation of the G ...
Leto: 2025 Vir: Biotehniška fakulteta (UL BF)
The Opposite Ends of Supersymmetry and their Implications for the LHC
James Wells
Video in druga učna gradiva
Oznake: physics
There have been many predictions for the mass patterns of superpartners. In these lectures I discuss two interesting opposite-end approaches to supersymmetry breaking that determine the superpartner masses: zero scalar mass supersymmetry (no scale, gaugino mediation, etc.) and heavy scalar mass supe ...
Leto: 2009 Vir: videolectures.net
Welcome presentation/ Computer security/ Workshop presentation
James Wells , Dale Myers , Niko Neufeld , Ingrid Schmid
Video in druga učna gradiva
Oznake: physics
Leto: 2009 Vir: videolectures.net
Exploring annotations for musical pattern discovery gathered with digital annotation tools
Darian Tomašević, Stephan Wells, Iris Yuping Ren, Anja Volk, Matevž Pesek
Izvirni znanstveni članek
Oznake: glasbeni vzorec;digitalna orodja za anotacijo;strinjanje anotatorjev;analiza značilk;musical pattern;digital annotation tool;inter-annotator agreement;feature analysis;
The study of inter-annotator agreement in musical pattern annotations has gained increased attention over the past few years. While expert annotations are often taken as the reference for evaluating pattern discovery algorithms, relying on just one reference is not usually sufficient to capture the ...
Leto: 2021 Vir: Fakulteta za računalništvo in informatiko (UL FRI)
Toll-like receptor 1 polymorphism is associated with impaired immune tolerance, dysregulated inflammatory responses to Borrelia burgdorferi, and heightened risk of post-infectious Lyme arthritis
Morgan A. Williams, Sergio A. Hernández, Sheila Arvikar, Katherine B. Sulka, Franc Strle, Christopher C. Wells, Tanja Petnicki-Ocwieja, Allen C. Steere, Klemen Strle
Izvirni znanstveni članek
Oznake: Lyme disease;Borrelia burgdorferi;toll-like receptors;innate immune tolerance;inflammation;Lyme arthritis;innate immunology;
Introduction: Clinical presentation of Lyme disease is largely due to host immune response to infection. Previously, we identified a variant (1805GG) in the TLR1 gene, a key immune sensor for Borrelia burgdorferi, which was associated with excessive inflammation and severe disease. Herein we examine ...
Leto: 2025 Vir: Repozitorij Univerze v Ljubljani (RUL)
Critical uncertainties in preclinical research
Indrek Heinla, Vootele Voikar, Hilary Gates, Rasneer Sonia Bains, Sara Wells, Silvia Mandillo, Maša Čater, Kristi Kukk, Lars Lewejohann, Dragan Hrnčić, Daniela Duarte-Domingues, Philipp Villiger, Leonardo Restivo, Sabine M. Hölter
Kratki znanstveni prispevek
Oznake: poskusne živali;znanstvene raziskave;etika;tehnologija;zaupanje v znanost;new approach methodologies;animal research;strategic foresight;scenarios;trust in science;competitiveness;
Animal use in preclinical research is facing growing scientific, ethical and political scrutiny in Europe. Researchers are increasingly required to justify in vivo studies and are urged to replace them with New Approach Methodologies (NAMs), even where these are not yet fit for purpose. In response ...
Leto: 2026 Vir: Biotehniška fakulteta (UL BF)
Št. zadetkov: 6
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