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Repurposing of compound libraries yields new inhibitors of NDM-1 metallo-β-lactamase with diverse zinc-binding moieties
Vid Kavaš, Philip Hinchliffe, Maša Zorman, Alen Krajnc, Matic Proj, Majda Golob, Martina Hrast, James Spencer, Stanislav Gobec
Izvirni znanstveni članek
Oznake: mercaptoamides;New Delhi metallo-β-lactamase inhibitors;zinc-binding group library;in silico design;
Antimicrobial resistance has emerged as a critical global public health threat, impacting human, animal and environmental health. An important mechanism of resistance is the production of β-lactamases, enzymes that hydrolyze the β-lactam ring, rendering β-lactam antibiotics ineffective. Metallo-β-la ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Burden of injury along the development spectrum
Juanita A Haagsma, Spencer L. James, Chris D. Castle, Zachary V. Dingels, Jack T. Fox, Erin B. Hamilton, Zichen Liu, Lydia R. Lucchesi, Nicholas L S. Roberts, Diego De Leo
Izvirni znanstveni članek
Oznake: poškodbe;socio-demografski indeks (SDI);življenje prilagojeno invalidom;injury;Socio-demographic Index (SDI);disability-adjusted life;
Leto: 2020 Vir: Univerza na Primorskem (UP)
Št. zadetkov: 2
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