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ǂA ǂtwo-dimensional hyphenated ion-exchange chromatographic platform for simultaneous assessment of AAV8 capsids and impurity fingerprinting in upstream processes
Timotej Žvanut, Tjaša Kašček, Lara Vogrinčič, Petra Dekleva, Sandra Hasić, Anže Martinčič Celjar, Ivana Petrović Koshmak, Blaž Goričar, Mitja Martelanc, Aleš Štrancar, Andreja Gramc-Livk
Izvirni znanstveni članek
Oznake: complex samples;upstream process monitoring;two-dimensional hyphenated liquid chromatography;Adeno-associated virus;full capsid content;
Reliable monitoring of full (F) versus empty (E) adeno-associated virus (AAV) capsids, along with impurity fingerprinting, is essential for optimising upstream processes (USPs). Conventional analytical workflows for USP monitoring, including PCR-ELISA and one-dimensional (1D) liquid chromatography ( ...
Leto: 2026 Vir: Univerza v Novi Gorici (UNG)
Št. zadetkov: 1
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