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Št. zadetkov: 2
Lipophilic cations as mitochondria-targeting moieties: recent progress and design principles for medicinal chemistry
Ivan Džajić, Tihomir Tomašić, Luis A. Pardo, Lucija Peterlin-Mašič, Andrej Emanuel Cotman
Pregledni znanstveni članek
Oznake: assays;cations;conjugate acid-base pairs;mitochondria;sensor probes;
Mitochondria-targeting technology, in the form of (lipophilic cation)–(small molecule) conjugates, was first discussed more than 50 years ago. Since then, the triphenylphosphonium (TPP) cation has become synonymous with the concept of a mitochondria-targeting moiety (MTM). The discovery of its abili ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
New mitochondrial K[sub](V)1.3 conjugates are potent and specific inducers of apoptosis in cancer models
Špela Gubič, Marzia Fois, Ivan Džajić, Katja Kološa, Alja Štraser, Maša Bošnjak, Tim Božič, Boštjan Markelc, Tanja Dolinšek, Maja Čemažar, Bojana Žegura, Tina Kosjek, Andrej Emanuel Cotman, Tihomir Tomašić, Lucija Peterlin-Mašič
Izvirni znanstveni članek
Oznake: rak;biomedicina;mitohondrijske membrane;mitochondrial targeting;mitochondrial KV1.3;apoptosis;cancer;
New mitochondrial K[sub](V)1.3 conjugates are potent and specific inducers of apoptosis in cancer models
Leto: 2026 Vir: Repozitorij Univerze v Ljubljani (RUL)
Št. zadetkov: 2
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