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Lipophilic cations as mitochondria-targeting moieties: recent progress and design principles for medicinal chemistry
Ivan Džajić, Tihomir Tomašić, Luis A. Pardo, Lucija Peterlin-Mašič, Andrej Emanuel Cotman
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Oznake: assays;cations;conjugate acid-base pairs;mitochondria;sensor probes;
Mitochondria-targeting technology, in the form of (lipophilic cation)–(small molecule) conjugates, was first discussed more than 50 years ago. Since then, the triphenylphosphonium (TPP) cation has become synonymous with the concept of a mitochondria-targeting moiety (MTM). The discovery of its abili ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
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