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Št. zadetkov: 6
Ugotavljanje produktov razgradnje lignina z izbranimi sevi bakterij s tekočinsko kromatografijo, sklopljeno z masno spektrometrijo
Helena Plešnik, Jurij Trontelj, Tina Kosjek
Magistrsko delo
Oznake: lignin;bakterijska razgradnja;ekstrakcija na trdni fazi;tekočinska kromatografija;masna spektrometrija;
Lignin je kompleksen heterogen aromatski biopolimer, ki se nahaja v stenah rastlinskih celic kot ena izmed komponent lignoceluloze. Velike količine lignina nastajajo kot stranski produkt v papirni industriji in industriji biogoriv. Ker predstavlja bogat naravni vir aromatskega ogljika, bi lahko pote ...
Leto: 2020 Vir: Fakulteta za farmacijo (UL FFA)
ǂAn ǂeffective validation of analytical method for determination of a polar complexing agent
Helena Plešnik, Maša Bošnjak, Maja Čemažar, Gregor Serša, Tina Kosjek
Izvirni znanstveni članek
Oznake: liquid chromatography;mass spectrometry;biological;pharmaceutical;measurement uncertainty;stability;
The effectiveness of highly polar agents in cancer treatment is well recognized, but their physicochemical properties make their analytical determination a demanding task. Their analysis requires peculiar sample preparation and chromatographic separation, which heavily impacts the precision of such ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Quantitative analysis of trace-level bleomycin in complex matrices
Helena Plešnik, Angelika Vižintin, Damijan Miklavčič, Jack Steed, Jianru Stahl-Zeng, Tina Kosjek
Izvirni znanstveni članek
Oznake: bleomicin;elektrokemoterapija;natančnost meritev;bleomycin;electrochemotherapy;trace level;tandem mass spectrometry;sensitivity;
Bleomycin, a cytotoxic antibiotic, poses substantial challenges for mass spectrometry-based analysis due to its extreme polarity, chelating properties, heterogeneity of fractions, and propensity to form multiple charged species during electrospray ionization. As one of the few effective drugs used i ...
Leto: 2025 Vir: Fakulteta za elektrotehniko (UL FE)
Bleomycin concentration in patientsʹ plasma and tumors after electrochemotherapy
Aleš Grošelj, Maša Bošnjak, Mojca Kržan, Tina Kosjek, Krisztina Bottyán, Helena Plešnik, Črt Jamšek, Maja Čemažar, Erika Kis, Gregor Serša
Izvirni znanstveni članek
Oznake: elektrokemoterapija;elektroporacija;bleomycin;electrochemotherapy;electroporation;
Bleomycin concentration in patientsʹ plasma and tumors after electrochemotherapy
Leto: 2021 Vir: Onkološki inštitut Ljubljana (OI)
Pharmacokinetics of single dose levobupivacaine after peri-incisional subcutaneous infiltration in anaesthetized domestic pigs
Tilen Vake, Tomaž Snoj, Maja Čemažar, Urša Lampreht Tratar, Urban Stupan, Alenka Seliškar, Jan Plut, Tina Kosjek, Helena Plešnik, Marina Štukelj
Izvirni znanstveni članek
Oznake: bupivacaine;levobupivacaine;anaesthetic;local anaesthesia;analgesia;pharmacokinetics;pigs;porcine;
Increasing use of pigs as models in translational research, and growing focus on animal welfare are leading to better use of effective analgesics and anaesthetics when painful procedures are performed. However, there is a gap in basic knowledge such as pharmacokinetics of different anaesthetics in t ...
Leto: 2024 Vir: Veterinarska fakulteta (UL VF)
Nontargeted urinary profiling strategy for endocrine-disrupting chemicals in women with ovarian malignancies
Helena Plešnik, Žan Rekar, Stefanela Stevanović, Irma Virant-Klun, Senka Imamović-Kumalić, Mateja Sladič, Darja Mazej, Janja Snoj Tratnik, Milena Horvat, Tina Kosjek
Izvirni znanstveni članek
Oznake: ovarian cancer;biomarkers;exposure;
Endocrine-disrupting chemicals (EDCs), includingknown and unknown parent compounds, their metabolites, andtransformation products, are pervasive in daily life, posingincreasing risks to human health and the environment. Thisstudy employed a high-resolution mass spectrometry-basednontargeted screenin ...
Leto: 2025 Vir: Fakulteta za računalništvo in informatiko (UL FRI)
Št. zadetkov: 6
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