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Towards a digital twin of primary drying in lyophilization using coupled 3-D equipment CFD and 1-D vial-scale simulations
Matej Zadravec, Efimia Metsi-Guckel, Blaž Kamenik, Johan Remelgas, Johannes G. Khinast, Nick Roscioli, Matthew Flamm, Harshil Renawala, Jeff Najarian, Atul Karande, Avik Sarkar
Izvirni znanstveni članek
Oznake: liofilizacija;sušenje z zamrzovanjem;sublimacijsko sušenje;lyophilization;freeze-drying;sublimation;
A digital twin of lyophilization units was developed to facilitate the scale-up of the lyophilization process from the laboratory to the commercial scale. Our focus was on ensuring successful technology transfer for manufacture of high-quality drug products. Traditionally, lyophilization models have ...
Leto: 2024 Vir: Fakulteta za strojništvo (UM FS)
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