Iskalni niz:
išči po
išči po
išči po
išči po
Vrsta gradiva:
Jezik:
Št. zadetkov: 3
Design and synthesis of novel 3-triazolyl-1-thiogalactosides as galectin-1, -3 and -8 inhibitors
Sjors van Klaveren, Jaka Dernovšek, Žiga Jakopin, Marko Anderluh, Hakon Leffler, Ulf Nilsson, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: β-galaktozid;galektini;raziskava zdravil;diklorotiofenilni analog 59;
Galectins are galactoside-binding proteins that play a role in various pathophysiological conditions, making them attractive targets in drug discovery. We have designed and synthesised a focused library of aromatic 3-triazolyl-1-thiogalactosides targeting their core site for binding of galactose and ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Structure-guided design of D-galactal derivatives with high affinity and selectivity for the galectin-8 n-terminal domain
Mujtaba Hassan, Floriane Baussière, Samo Guzelj, Anders Sundin, Maria Håkansson, Rebeka Kovačič, Hakon Leffler, Tihomir Tomašić, Marko Anderluh, Žiga Jakopin
Izvirni znanstveni članek
Oznake: Galectin-8N;d-galactal;benzimidazole;selectivity;X-ray crystallography;cytokine secretion;
Galectin-8 is a carbohydrate-binding protein that plays a crucial role in tumor progression and metastasis, antibacterial autophagy, modulation of the immune system, and bone remodeling. The design, synthesis, and protein affinity evaluation of a set of C-3 substituted benzimidazole and quinoline d- ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Nanomolar inhibitor of the galectin-8 N-terminal domain binds via a non-canonical cation-π interaction
Edvin Purić, Mujtaba Hassan, Fredrik Sjövall, Tihomir Tomašić, Mojca Pevec, Jurij Lah, Jaume Adrover Forteza, Anders Sundin, Hakon Leffler, Ulf Nilsson, Derek T. Logan, Marko Anderluh
Izvirni znanstveni članek
Oznake: carbohydrates;lead optimization;structure-based drug design;X-ray crystallography;
Galectin-8 is a tandem-repeat galectin consisting of two distinct carbohydrate recognition domains and is a potential drug target. We have developed a library of galectin-8N inhibitors that exhibit high nanomolar Kd values as determined by a competitive fluorescence polarization assay. A detailed th ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 3
Ključne besede:
Leto izdaje:
Avtorji:
Repozitorij:
Tipologija:
Jezik: