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Št. zadetkov: 6
Research progress and applications of multivalent, multispecific and modified nanobodies for disease treatment
Jiewen Wang, Guangbo Kang, Haibin Yuan, Xiaocang Cao, He Huang, Ario De Marco
Pregledni znanstveni članek
Oznake: nanobody multimers;immunomodulation;intrabodies;imaging;nanobody functionalization;
Research progress and applications of multivalent, multispecific and modified nanobodies for disease treatment
Leto: 2022 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Novel bispecific nanobody mitigates experimental intestinal inflammation in mice by targeting TNF-[alpha] and IL-23p19 bioactivities
Jiewen Wang, Guangbo Kang, Huiying Lu, Ario De Marco, Haibin Yuan, Zelin Feng, Mengxue Gao, Xiaoli Wang, Huahong Wang, Xiaolan Zhang
Izvirni znanstveni članek
Oznake: bispecific constructs;nanobodies;intestinal inflammation;
Leto: 2024 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Development and characterization of CR101-ADC, a fully-human anti-claudin18.2 monoclonal antibody-drug conjugate
Miao Zhang, Haibin Yuan, Xian Li, Jianan Yin, Fei Qi, Junjie Chen, Jiatao Zhou, Xiaolong Wang, Shuping Zhang, Ario De Marco
Izvirni znanstveni članek
Oznake: claudin 18.2;antibody-drug conjugate;tumor therapy;
Leto: 2026 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Noncanonical amino acid-aided synthesis of anti-PD-L1 bispecific nanobody for colon cancer immunotherapy
Xinyu Hu Hu, Ling Jiang, Haibin Yuan, Wanyi Chen, Yufei Guo, Mengxue Gao, Yijia Song, Zichen Wang, Yuli Wang, Ario De Marco
Izvirni znanstveni članek
Oznake: nanobody;immunotherapy;PD-L1;non-canonical amino-acids;
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality, and the incidence of early-onset colon cancer has been increasing globally in recent years. The development of immunotherapies for colon cancer is critical for providing new treatment strategies to combat drug resist ...
Leto: 2025 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Design of nanobody-based bispecific constructs by in silico affinity maturation and umbrella sampling simulations
Zixuan Bai, Jiewen Wang, Jiaqi Liu, Haibin Yuan, Ping Wang, Miao Zhang, Yuanhang Feng, Xiangtong Cao, Xiangan Cao, Guangbo Kang, Ario De Marco, He Huang
Izvirni znanstveni članek
Oznake: nanobody rational design;bispecific binders;protein activity inhibition;
Design of nanobody-based bispecific constructs by in silico affinity maturation and umbrella sampling simulations
Leto: 2023 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Affinity maturation of antibody fragments
Jiaqi Liu, Guangbo Kang, Jiewen Wang, Haibin Yuan, Yili Wu, Shuxian Meng, Ping Wang, Miao Zhang, Yuli Wang, Yuanhang Feng, He Huang, Ario De Marco
Pregledni znanstveni članek
Oznake: deep learning;protein modeling;random mutagenesis;rational mutagenesis;
Affinity maturation of antibody fragments
Leto: 2023 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Št. zadetkov: 6
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