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Št. zadetkov: 2
Unveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids
Goran Poje, Davor Šakić, Marina Marinovich, Jiangyang You, Michael Tarpley, Kevin P. Williams, Nikolina Golub, Jaka Dernovšek, Tihomir Tomašić, Erim Bešić, Zrinka Rajić
Izvirni znanstveni članek
Oznake: harmine;β-carboline;ferrocene;hybrid compounds;antiproliferative activity;glioblastoma multiforme;Hsp90;DYRK1A;antioxidant activity;EPR spectroscopy;
The poor prognosis of glioblastoma multiforme, inadequate treatment options, and growing drug resistance urge the need to find new effective agents. Due to the significant anti-cancer potential of harmicens, hybrid compounds which comprise harmine/β-carboline and ferrocene moiety, we investigated th ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Exploration and optimisation of structure-activity relationships of new triazole-based C-terminal Hsp90 inhibitors towards in vivo anticancer potency
Jaka Dernovšek, Živa Zajec, Goran Poje, Dunja Urbančič, Tjaša Goričan, Simona Golič Grdadolnik, Irena Mlinarič-Raščan, Andrej Emanuel Cotman, Nace Zidar, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: cancer;Hsp90;inhibitor;Ewing sarcoma;zebrafish;
The development of new anticancer agents is one of the most urgent topics in drug discovery. Inhibition of molecular chaperone Hsp90 stands out as an approach that affects various oncogenic proteins in different types of cancer. These proteins rely on Hsp90 to obtain their functional structure, and ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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