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Št. zadetkov: 2
Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives
Maša Sinreih, Rebeka Jójárt, Zoltán Kele, Tomaž Büdefeld, Gábor Paragi, Erzsébet Mernyák, Tea Lanišnik-Rižner
Izvirni znanstveni članek
Oznake: aldo-keto reduktaze;halogenirani derivati estrona;zaviranje;
Facile syntheses of 3-O-carbamoyl, -sulfamoyl, or -pivaloyl derivatives of 13[alpha]-oestrone and its 17-deoxy counterpart have been carried out. Microwave-induced, Ni-catalysed Suzuki-Miyaura couplings of the newly synthesised phenol esters with phenylboronic acid afforded 3-deoxy-3-phenyl-13a-oest ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Targeting steroid-metabolizing enzymes with 15β-substituted estrone analogues
Vivien Resch, Marija Gjorgoska, Eva Hafner, Ildikó Bacsa, Benjamin Kovács, Tomaž Büdefeld, Attila Hunyadi, Ildikó Huliák, Mónika Kiricsi, Gábor Paragi, Tea Lanišnik-Rižner, Tea Lanišnik-Rižner
Izvirni znanstveni članek
Oznake: 17β-HSD1 enzyme;AKR1C1–3 enzymes;antiproliferative;chemoresistance;fluorescent labeling;inhibitor;
Background/objectives: Aldo-keto reductase isoforms AKR1C1-3 and 17β-hydroxysteroid dehydrogenase 1 and 2 (17β-HSD1 and 17β-HSD2) are key enzymes in steroid metabolism and validated targets in hormone-dependent cancers. Methods: In this study, Δ15- and 15β-substituted estrone derivatives were evalua ...
Leto: 2026 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 2
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