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Št. zadetkov: 4
Pharmacogenomics of thiopurines on Kosovo population
Flaka Pasha, Irena Mlinarič Raščan, Shaip Krasniqi
Doktorska disertacija
Oznake: thiopurines;pharmacogenomics;therapeutic drug monitoring;overall survival;adverse outcomes;
This dissertation evaluates the efficacy and safety of thiopurine treatment in patients with acute lymphoblastic leukemia (ALL), inflammatory bowel disease (IBD), and autoimmune disorders in Kosovo. Herein, we present identified and validated genetic polymorphisms affecting thiopurine metabolism, an ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Personalization of thiopurine therapy
Dunja Urbančič, Flaka Pasha, Alenka Šmid, Irena Mlinarič-Raščan
Pregledni znanstveni članek
Oznake: thiopurines;TPMT;NUDT15;personalized medicine;therapeutic drug monitoring;
Despite great therapeutic advances in the field of biologics, small synthetic molecules such as thiopurines, including azathioprine, mercaptopurine, and thioguanine, remain an important therapeutic pillar in the treatment of inflammatory bowel disease, other autoimmune disorders, and cancer. This re ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Prevalence and treatment outcomes of childhood acute lymphoblastic leukemia in Kosovo
Flaka Pasha, Dunja Urbančič, Rufadie Maxhuni, Shaip Krasniqi, Violeta Grajçevci Uka, Irena Mlinarič-Raščan
Izvirni znanstveni članek
Oznake: splošno preživetje;preživetje brez dogodkov;acute lymphoblastic leukemia;treatment;overall survival;event-free survival;pediatric;
Advances in research, including novel biomarker identification and patient stratification, have significantly improved the therapy for childhood acute lymphoblastic leukemia (ALL), though access to improved healthcare services varies across geographical regions. In an effort to evaluate the advances ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Population frequencies of thiopurine-related pharmacogenes in healthy individuals from Kosovo
Flaka Pasha, Dunja Urbančič, Gordana Gosheva, Bukurije Zhubi, Safete Maliqi Qormemeti, Shaip Krasniqi, Irena Mlinarič-Raščan, Irena Mlinarič-Raščan
Izvirni znanstveni članek
Oznake: genetics research;pharmacogenomics;
Personalized thiopurine therapy is among the most established examples of pharmacogenomics translated into clinical practice. Variants in TPMT (rs1800462, rs1800460, rs1142345) and NUDT15 (rs116855232) are recognized clinical predictors of thiopurine efficacy and toxicity. Additional variants in gen ...
Leto: 2026 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 4
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