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Št. zadetkov: 2
Targeting voltage-gated proton channel H[sub]V1
Martina Piga, Geraldo Jorge Domingos, Ádám Fehér, Ferenc Papp, Kavya C. Bangera, Zoltán Varga, Florina Zakany, Tamas Kovacs, Jaka Dernovšek, Tihomir Tomašić, Nace Zidar
Izvirni znanstveni članek
Oznake: anticancer;HV1;inhibitor;5-phenyl-2-aminoimidazole;voltage-gated proton channel;
The voltage-gated proton channel (HV1) has been linked to the development of tumours, neuroinflammatory diseases, immune disorders and infertility, making HV1 inhibitors promising candidates for therapeutic development. In this study, we designed and synthesized an optimised series of 5-phenyl-2-ami ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Identification of a novel structural class of H[sub]v1 inhibitors by structure-based virtual screening
Martina Piga, Zoltán Varga, Ádám Fehér, Ferenc Papp, Eva Korpos Pintye-Gyuri, Kavya C. Bangera, Rok Frlan, Janez Ilaš, Jaka Dernovšek, Tihomir Tomašić, Nace Zidar
Izvirni znanstveni članek
Oznake: cancer;cells;inhibition;inhibitors;screening assays;
The human voltage-gated proton channel, hHv1, is highly expressed in various cell types including macrophages, B lymphocytes, microglia, sperm cells and also in various cancer cells. Overexpression of Hv1 has been shown to promote tumor formation by highly metastatic cancer cells, and has been assoc ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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