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Design, synthesis and biological evaluation of novel pyrimidine and quinazoline-based small-molecule Toll-like receptor 8 antagonists
Troy Matziol, Valerij Talagayev, Nika Strašek, Felicitas Lauber, Paula von Kempis, Tjaša Slokan, Janine Holze, Erika Kulitzki, Günther Weindl, Günther Weindl, Matej Sova, Matej Sova
Izvirni znanstveni članek
Oznake: Toll-like receptors;TLR8;anti-inflammatory;drug discovery;pyrimidine;quinazoline;antagonists;
Toll-like receptor 8 (TLR8) plays a key role in inflammatory and autoimmune disease pathogenesis. The development of TLR8 antagonists has therefore increased in recent years, however, no clinical candidates have yet reached the market. Here, we report a novel chemotype of selective TLR8 antagonists ...
Leto: 2026 Vir: Fakulteta za farmacijo (UL FFA)
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