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Št. zadetkov: 9
Alterations in Muscle Contractile Properties, Structure, and Function During 10-Day Bed Rest, Post-Recovery, and Following COVID-19 Lockdown
Boštjan Šimunič, Martino V. Franchi, Fabio Sarto, Elena Monti
Raziskovalni podatki
Oznake: Atrophy;Bed rest;Physical inactivity;Skeletal muscle;Tensiomyography;
We aimed to identify early tensiomyography alterations in six muscles during a 10-day bed rest (BR10), followed by a 30-day recovery period (R+30), and to compare these changes with those observed after the 54-day COVID-19 lockdown in ten healthy males (22.9 ± 5.0 years). Tensiomyography and muscle ...
Leto: 0 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Potential of synergist ablation to study mechanisms of skeletal muscle hypertrophy in rodent disease models
Fabio Sarto, Christopher S. Fry, Marco Narici, Lee L. Rubin, Feodor D. Price
Kratki znanstveni prispevek
Oznake: muscles;cancer cachexia;exercise;metabolic disorders;neuromuscular disorders;resistance training;
Synergist ablation (SA) is a well-established model of mechanical overload-induced hypertrophy in rodents, commonly used toinfer skeletal muscle adaptation to resistance training in humans. Given the critical role of skeletal muscle atrophy in chronicconditions such as neuromuscular, metabolic, and ...
Leto: 2025 Vir: Repozitorij Univerze na Primorskem (RUP)
Pathophysiological mechanisms of reduced physical activity
Fabio Sarto, Roberto Bottinelli, Martino V. Franchi, Simone Porcelli, Boštjan Šimunič, Rado Pišot, Marco Narici
Pregledni znanstveni članek
Oznake: telesna neaktivnost;inzulinska občutljivost;physical inactivity;cage reduction;insulin sensitivity;muscle atrophy;
Physical inactivity represents a heavy burden for modern societies and is spreading worldwide, it is a recognised pandemic and is the fourth cause of global mortality. Not surprisingly, there is an increasing interest in longitudinal studies on the impact of reduced physical activity on different ph ...
Leto: 2023 Vir: Univerza na Primorskem (UP)
Upregulation of sarcolemmal hemichannels and inflammatory transcripts with neuromuscular junction instability during lower limb unloading in humans
Giuseppe Sirago, Julián Candia, Martino V. Franchi, Fabio Sarto, Elena Monti, Luana Toniolo, Carlo Reggiani, Emiliana Giacomello, Sandra Zampieri, Marco Narici
Izvirni znanstveni članek
Oznake: miščnoskeletni sistem;skeletne mišice;živčno-mišični spoj;sarkolemski hemokanali;spodnje okončine;skeletal muscles;neuromuscular junction;sarcolemmal hemichannels;lower limb;
Upregulation of sarcolemmal hemichannels and inflammatory transcripts with neuromuscular junction instability during lower limb unloading in humans
Leto: 2023 Vir: Univerza na Primorskem (UP)
Effects of a 2-year exercise training on neuromuscular system health in older individuals with low muscle function
Elena Monti, Sara Tagliaferri, Sandra Zampieri, Fabio Sarto, Giuseppe Sirago, Martino V. Franchi, Andrea Ticinesi, Yari Longobucco, Elisa Adorni, Marco Narici
Izvirni znanstveni članek
Oznake: miščnoskeletni sistem;skeletne mišice;fragment C-terminalnega agrina;lahke verige živčnih nitk;vadbene intervencije;sarkopenija;starostniki;skeletal muscles;C-terminal agrin fragment;neurofilament light chain;exercise interventions;sarcopenia;elderly;
Effects of a 2-year exercise training on neuromuscular system health in older individuals with low muscle function
Leto: 2023 Vir: Univerza na Primorskem (UP)
Neuromuscular junction instability with inactivity
Evgeniia Motanova, Fabio Sarto, Samuele Negro, Marco Pirazzini, Ornella Rossetto, Michela Rigoni, Daniel W Stashuk, Mladen Gasparini, Boštjan Šimunič, Rado Pišot, Marco Narici
Izvirni znanstveni članek
Oznake: ageing;C-terminal agrin;fragment disuse;electromyography;motor unit;NMJ unloading;
The neuromuscular junction (NMJ) plays a key role in modulating muscle contraction,but the impact of short-term disuse on NMJ structure and function, particularly in older humans,remains unclear. This study aimed to investigate NMJ alterations following 10 days of horizontalbed rest in 10 older male ...
Leto: 2025 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Previous short-term disuse dictates muscle geneexpression and physiological adaptations to subsequentresistance exercise
Martino V. Franchi, Julián Candia, Fabio Sarto, Giuseppe Sirago, Giacomo Valli, Matteo Paganini, Lisa M. Hartnell, Emiliana Giacomello, Luana Toniolo, Elena Monti, Leonardo Nogara, Tatiana Moro, Marco Narici
Izvirni znanstveni članek
Oznake: fiziologija vadbe;izražanje genov;prilagoditev mišic;atrofičnost mišic;mišična fiziologija;mišična plastičnost;trening z uporom;odzivi na razbremenitev;exercise physiology;gene expression;muscle adaptation;muscle atrophy;musle physiology;muscle plasticity;resistance training;unloading responses;
Short-term unloading experienced following injury or hospitalisation induces muscle atrophy and weakness. The effects of exercise following unloading have been scarcely investigated. We investigated the functional and molecular adaptations to a resistance training (RT) programme following short-term ...
Leto: 2025 Vir: Repozitorij Univerze na Primorskem (RUP)
Changes in motor unit conduction velocity after unilaterallower-limb suspension and active recovery are correlated withmuscle ion channel gene expression
Giacomo Valli, Fabio Sarto, Francesco Negro, Elena Monti, Giuseppe Sirago, Matteo Paganini, Sandra Zampieri, Martino V. Franchi, Andrea Casolo, Julián Candia, Luigi Ferrucci, Marco Narici, Giuseppe De Vito
Izvirni znanstveni članek
Oznake: ion channel;mRNA sequencing;muscle fibre diameter;muscle unloading;neuromuscular impairment;
The effects of muscle disuse on the propagation of action potentials along motorunit (MU) muscle fibres, a key process for effective muscle activation and forcegeneration, remain poorly understood. The aim of this study was to investigate changesin action potential propagation and to identify biolog ...
Leto: 2025 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Twenty-one days of bed rest alter motor unit properties and neuromuscular junction transmission in young adults
Fabio Sarto, Miloš Kalc, Evgeniia Motanova, Martino V. Franchi, Daniel W Stashuk, Nina Murks, Giacomo Valli, Samuele Negro, Tomaž Prašnikar, Mladen Gasparini, Giovanni Martino, Giuseppe De Vito, Aleš Holobar, Boštjan Šimunič, Rado Pišot, Marco Narici
Izvirni znanstveni članek
Oznake: neuporaba;razbremenitev;fizična neaktivnost;elektrofiziologija;elektromiografija;disuse;unloading;physical inactivity;electrophysiology;electromyography;
Previous studies showed that properties of higher‐threshold motor units (MUs) and neuromuscular junction (NMJ) function are preserved during short‐term disuse. This study aimed to test how a longer disuse period affects MU properties, NMJ transmission, and NMJ morphology remodeling. Nine young healt ...
Leto: 2025 Vir: Repozitorij Univerze na Primorskem (RUP)
Št. zadetkov: 9
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