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The diagnostic tool to detect early stages of Alzheimer’s Disease, a progressive neurodegenerative disease, is lacking until today. FDG-PET (Fluorodeoxyglucose-Positron Emission Tomography) shows hypometabolic areas in the brains of pre-demented, i.e. patients suffering from mild cognitive impair ...

Pancreatic β-cells, which are a highly plastic, heterogeneous group of cells, produce insulin and have a key role in glucose homeostasis. Because malfunctioning of β-cells causes diabetes, they represent a potential target for diabetes regenerative therapies. Since most diabetes studies are done on ...

This study investigates how sample preparation, storage, and processing impact gene expression analysis in single cells of pancreatic islets, with an emphasis on distinguishing technical artefacts from actual biological changes, especially in the context of Type 2 Diabetes (T2D). We found that batch ...

This study explores the evaluation of perturbation prediction models in single-cell RNA sequencing through the application of alternative metrics, beyond the commonly used correlation and R-squared. Nine evaluation metrics, cosine distance, Euclidean distance, log-likelihood, maximum mean discrepanc ...