Št. zadetkov: 10
Doktorska disertacija
Oznake:
beta cell;tissue slice;GLP-1 receptor agonists;confocal microscopy;calcium oscillations;
Natančno uravnavanje sklopitve stimulacije in izločanja v celicah beta je ključnega pomena za vzdrževanje normoglikemije. Čeprav glukoza v tem procesu predstavlja primarni dražljaj, inkretini ključno prispevajo k povečanemu izločanju inzulina, delno tudi preko ojačitve znotrajcelične dinamike [Ca2+] ...
Leto:
2024
Vir:
Medicinska fakulteta (UM MF)
Pregledni znanstveni članek
Oznake:
cAMP;beta cells;stimulus-secretion coupling;intercellular coupling;PKA;Epac2A;
Pancreatic beta cells secrete insulin in response to stimulation with glucose and other nutrients, and impaired insulin secretion plays a central role in development of diabetes mellitus. Pharmacological management of diabetes includes various antidiabetic drugs, including incretins. The incretin ho ...
Leto:
2021
Vir:
Medicinska fakulteta (UM MF)
Pregledni znanstveni članek
Oznake:
in vitro disease models;pancreas;islet of Langerhans;3D cell culture;scaffolds;acute tissue slices;
The ethical constraints and shortcomings of animal models, combined with the demand to study disease pathogenesis under controlled conditions, are giving rise to a new field at the interface of tissue engineering and pathophysiology, which focuses on the development of in vitro models of disease. In ...
Leto:
2021
Vir:
Medicinska fakulteta (UM MF)
Objavljeni povzetek znanstvenega prispevka na konferenci
Oznake:
acute pancreatitis;calcium imaging;LiveDead assay;pancreatic tissue slices;histological analysis;
Leto:
2025
Vir:
Medicinska fakulteta (UM MF)
Izvirni znanstveni članek
Oznake:
acute pancreatitis;pancreatic tissue damage;exocrine and endocrine interactions;live cell imaging;confocal laser scanning microscopy;calcium imaging;live/dead assay;tissue slice preparation;histological grading;
Acute pancreatitis (AP) is a sudden inflammation of the exocrine part of the pancreas, resulting in self-digestion and destruction of exocrine tissue. The intricate relationship between exocrine and endocrine functions is pivotal, as damage to acinar cells can affect endocrine cell function and vice ...
Leto:
2025
Vir:
Medicinska fakulteta (UM MF)
Izvirni znanstveni članek
Oznake:
Langerhansovi otočki;celice beta;kalcijeva signalizacija;medcelična komunikacija;funkcionalna omrežja;islets of Langerhans;beta cells;calcium signaling;intercellular communication;functional networks;myosin model;
Within the islets of Langerhans, beta cells orchestrate synchronized insulin secretion, a pivotal aspect of metabolic homeostasis. Despite the inherent heterogeneity and multimodal activity of individual cells, intercellular coupling acts as a homogenizing force, enabling coordinated responses throu ...
Leto:
2024
Vir:
Medicinska fakulteta (UM MF)
Izvirni znanstveni članek
Oznake:
beta cells;calcium imaging;ellagitannins;glucose intolerance;insulin resistance;metabolic syndrome;mouse model;western diet;
Background: Western diet (WD) consumption accelerates the development of metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). This study investigated whether chestnut-derived ellagitannins (FT50) modulate early metabolic alterations associated with WD feeding in C57BL/6J male mice. Methods ...
Leto:
2026
Vir:
Medicinska fakulteta (UM MF)
Pregledni znanstveni članek
Oznake:
pancreatic islets;beta cells;calcium imaging;intercellular communication;functional networks;multilayer networks;
Islets of Langerhans are multicellular microorgans located in the pancreas that play a central role in whole-body energy homeostasis. Through secretion of insulin and other hormones they regulate postprandial storage and interprandial usage of energy-rich nutrients. In these clusters of hormone-secr ...
Leto:
2022
Vir:
Medicinska fakulteta (UM MF)
Marko Šterk,
Jurij Dolenšek,
Maša Skelin,
Lidija Križančić Bombek,
Eva Paradiž,
Jasmina Kerčmar,
Matjaž Perc,
Marjan Rupnik,
Andraž Stožer,
Andraž Stožer,
Marko Gosak,
Marko Gosak
Izvirni znanstveni članek
Oznake:
islets of Langerhans;beta cells;insulin;
Leto:
2023
Vir:
Medicinska fakulteta (UM MF)
Diplomsko delo
Oznake:
norost;duševna bolezen;duševni bolnik;Foucault;Freud;
Diplomska naloga se ukvarja s tem, kako so obravnavali koncept norosti v 19. stoletju. Tematiko osvetli tako z zgodovinskega kot s filozofskega vidika. S filozofskega vidika je v ospredju Foucaultevo raziskovanje na tem področju ter vpliv Freuda in psihoanalize, ki se pojavi ob koncu stoletja, z zgo ...
Leto:
2020
Vir:
Filozofska fakulteta (UL FF)