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Modulating complex secondary metabolism in Streptomyces rimosus by targeted genome engineering
Martina Avbelj, Lucija Slemc, Alen Pšeničnik, Špela Zver, Anastasija Lazova, Kristina Mervič, Khan Mohammad Sarim, Maja Paš, Antonio Starcevic, Martin Šala, Miha Tome, Dušica Vujaklija, Hrvoje Petković
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Oznake: antibiotiki;oksitetraciklin;Streptomyces rimosus;biosinteza;gruča biosinteznih genov;sekundarni metaboliti;biosynthetic gene cluster;oxytetracycline;rimocidin;gene regulation;genome reduction;
Research background. Numerous biosynthetic gene clusters (BGCs) encoding unknown structures have been uncovered in the genomes of diverse microorganisms, representing a potentially rich source of novel natural products. However, the majority of the BGCs identified do not seem to be active, since we ...
Leto: 2026 Vir: Biotehniška fakulteta (UL BF)
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