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Disentangling the formation, mechanism, and evolvement of the covalent methanesulfonyl fluoride acetylcholinesterase adduct
Jure Stojan, Alessandro Pesaresi, Anže Meden, Doriano Lamba
Izvirni znanstveni članek
Oznake: acetylcholinesterase;enzyme aging;inactivation;reactivation;sulfonylation;
Chemical warfare nerve agents and pesticides, known as organophosphorus compounds inactivate cholinesterases (ChEs) by phosphorylating the serine hydroxyl group located at the active site of ChEs. Over the course of time, phosphorylation is followed by loss of an organophosphate-leaving group and th ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Distinct conformational changes occur within the intrinsically unstructured pro-domain of pro-Nerve Growth Factor in the presence of ATP and Mg [sup] 2+
Francesca Paoletti, Sonia Covaceuszach, Alberto Cassetta, Antonio N. Calabrese, Urban Novak, Peter Konarev, Jože Grdadolnik, Doriano Lamba, Simona Golič Grdadolnik
Izvirni znanstveni članek
Oznake: biokemija;apoptoza;NMR spektroskopija;ligandi;
Leto: 2023 Vir: Kemijski inštitut (KI)
Št. zadetkov: 2
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