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Št. zadetkov: 7
Strukturne, funkcijske in senzorne lastnosti sečnega mehurja na modelu intersticijskega cistitisa
Dominika Peskar, Andreja Erman
Doktorska disertacija
Oznake: intersticijski cistitis;mišji model;sečni mehur;urotelij;strukturne lastnosti;funkcijske lastnosti;senzorne lastnosti;
Intersticijski cistitis (IC) je kronično, aseptično vnetje sečnega mehurja, ki prizadene predvsem ženske. Klinični znaki, s katerimi se kaže IC, so podobni kot pri drugih obolenjih sečil, zato se IC pogosto diagnosticira napačno oz. do njegove končne diagnoze sploh ne pride. Ker etiologija in patofi ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
Molecular profiling of inflammatory processes in a mouse model of IC/BPS
Dominika Peskar, Tadeja Kuret, Katja Lakota, Andreja Erman
Izvirni znanstveni članek
Oznake: interstitial cystitis;inflammation;RNA sequencing;
Animal models are invaluable in the research of the pathophysiology of interstitial cystitis/bladder pain syndrome (IC/BPS), a chronic aseptic urinary bladder disease of unknown etiology that primarily affects women. Here, a mouse model of IC/BPS was induced with multiple low-dose cyclophosphamide ( ...
Leto: 2023 Vir: Repozitorij Univerze v Ljubljani (RUL)
ǂA ǂsystematic review of therapeutic approaches used in experimental models of interstitial cystitis/bladder pain syndrome
Tadeja Kuret, Dominika Peskar, Andreja Erman, Peter Veranič, Peter Veranič
Pregledni znanstveni članek
Oznake: interstitial cystitis;bladder pain syndrome;therapeutic approaches;
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a multifactorial, chronic bladder disorder with limited therapeutic options currently available. The present review provides an extensive overview of therapeutic approaches used in in vitro, ex vivo, and in vivo experimental models of IC/BPS. P ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Comprehensive transcriptome profiling of urothelial cells following TNFα stimulation in an in vitro interstitial cystitis/bladder pain syndrome model
Tadeja Kuret, Dominika Peskar, Mateja Erdani-Kreft, Andreja Erman, Peter Veranič, Peter Veranič
Izvirni znanstveni članek
Oznake: interstitial cystitis;bladder pain syndrome;urothelial cells;
Urothelial cells of the urinary bladder play a critical role in the development and progression of interstitial cystitis/bladder pain syndrome (IC/BPS), a chronic and debilitating inflammatory disease. Given the lack of data on the exact phenotype and function of urothelial cells in an inflammatory ...
Leto: 2022 Vir: Medicinska fakulteta (UL MF)
Sex-dependent differences in blood–urine barrier are subtle but significant in healthy and chronically inflamed mouse bladders
Dominika Peskar, Mojca Kerec Kos, Uroš Cerkvenik, Alenka Nemec Svete, Andreja Erman
Izvirni znanstveni članek
Oznake: bladder;blood–urine barrier;chronic cystitis;sex differences;
The urothelium is a vital permeability barrier that prevents the uncontrolled flow of urinary components into and out of the bladder interstitium. Our study addressed the question of possible sex-specific variations in the urothelium of healthy mice and their impact on chronic bladder inflammation. ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
miRNA expression profile as a potential tool for discrimination between bacterial and interstitial cystitis
Dominika Peskar, Nika Kojc, Andreja Erman, Andreja Erman, Emanuela Boštjančič, Emanuela Boštjančič, Iva Hafner Bratkovič
Izvirni znanstveni članek
Oznake: bacterial cystitis;expression analysis;inflammation;interstitial cystitis;microRNA;pathway analysis;reporter assay-validated targets;urinary bladde;
Introduction: Interstitial cystitis (IC) is an aseptic chronic bladder inflammation of unknown etiology and poorly understood pathophysiology with symptoms resembling bacterial cystitis (BC). There is limited data about the contribution of regulatory microRNAs (miRNAs) in IC. The study aimed to iden ...
Leto: 2026 Vir: Medicinska fakulteta (UL MF)
CBD promotes structural and functional epithelial restoration and alleviates inflammation in a mouse model of interstitial cystitis
Dominika Peskar, Mojca Kerec Kos, Špela Tavčar, Katja Lakota, Nika Kojc, Peter Veranič, Andreja Erman, Andreja Erman
Izvirni znanstveni članek
Oznake: urinary bladder;urothelium;permeability barrier;inflammation;interstitial cystitis;cannabidiol;cannabinoid receptors;
Background: Interstitial cystitis (IC) is a debilitating lower urinary tract condition characterised by chronic inflammation of the bladder. As the aetiology remains unknown, current treatments are symptomatic, aiming to reduce inflammation and pain. Cannabidiol (CBD), the most common cannabinoid in ...
Leto: 2026 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 7
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