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Nanomolar inhibitor of the galectin-8 N-terminal domain binds via a non-canonical cation-π interaction
Edvin Purić, Mujtaba Hassan, Fredrik Sjövall, Tihomir Tomašić, Mojca Pevec, Jurij Lah, Jaume Adrover Forteza, Anders Sundin, Hakon Leffler, Ulf Nilsson, Derek T. Logan, Marko Anderluh
Izvirni znanstveni članek
Oznake: carbohydrates;lead optimization;structure-based drug design;X-ray crystallography;
Galectin-8 is a tandem-repeat galectin consisting of two distinct carbohydrate recognition domains and is a potential drug target. We have developed a library of galectin-8N inhibitors that exhibit high nanomolar Kd values as determined by a competitive fluorescence polarization assay. A detailed th ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 1
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