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Št. zadetkov: 2
Repurposing medroxyprogesterone acetate and mefenamic acid for platinum-resistant ovarian cancer
Nika Marolt, Frederic Amant, Daniela Annibali, Tea Lanišnik-Rižner
Objavljeni povzetek znanstvenega prispevka na konferenci
Oznake: MPA;mefenamic acid;HGSOC;inhibition;AKRIC;ovarian cancer;
Repurposing medroxyprogesterone acetate and mefenamic acid for platinum-resistant ovarian cancer
Leto: 2025 Vir: Repozitorij Univerze v Ljubljani (RUL)
AKR1C inhibitors medroxyprogesterone acetate and mefenamic acid exhibit antitumor activity alone and combined with carboplatin in platinum-resistant high-grade serous ovarian cancer models
Nika Marolt, Alja Zottel, Daniela Annibali, Frederic Amant, Tea Lanišnik-Rižner, Tea Lanišnik-Rižner
Izvirni znanstveni članek
Oznake: Aldo-keto reductase;drug repurposing;high-grade serous ovarian cancer;medroxyprogesterone acetate;mefenamic acid;platinum resistance;prognostic biomarkers;
High-grade serous ovarian carcinoma (HGSOC) is the most lethal form of ovarian carcinoma, primarily because of its tendency to develop platinum resistance. The genes AKR1C1-3 and NFE2L2 are involved in steroid metabolism and cellular detoxification, but their roles in HGSOC remain unclear. Here, we ...
Leto: 2026 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 2
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