Št. zadetkov: 11
Doktorska disertacija
Oznake:
holesterol;steroli;RORC;HepG2;CRISPR-Cas9;sinteza holesterola;cirkadiana ura;CYP51A1;DHCR24;SC5D;HSD17B7;
Holesterol je esencialna molekula, glavni sterol v vseh celicah sesalcev in eden od ključnih komponent celičnih membran. Določa strukturne in funkcionalne parametre membran in je tudi sestavni del lipidnih raftov. Je predhodnik steroidnih hormonov, žolčnih kislin in oksidiranih oblik holesterola. Si ...
Leto:
2023
Vir:
Medicinska fakulteta (UL MF)
Magistrsko delo
Oznake:
metabolizem/astrociti/oleinska kislina/TAK875/GPR40/cAMP/FRET/Ca2+;
Astrociti imajo številne pomembne funkcije v centralnem živčnem sistemu. Med njimi je sodelovanje pri metabolizmu, saj presnavljajo glukozo v laktat, ki ga lahko nato posredujejo nevronom. Metabolizem astrocitov je natančno uravnan s strani z G-proteini sklopljenih receptorjev, med katere uvrščamo t ...
Leto:
2017
Vir:
Biotehniška fakulteta (UL BF)
Izvirni znanstveni članek
Oznake:
holesterol;sinteza holesterola;sterolni intermediati;cholesterol;cholesterol synthesis;sterol intermediates;
We developed a simple and robust liquid chromatographic/mass spectrometric method (LC-MS) for the quantitative analysis of 10 sterols from the late part of cholesterol synthesis (zymosterol, dehydrolathosterol, 7-dehydrodesmosterol, desmosterol, zymostenol, lathosterol, FFMAS, TMAS, lanosterol, and ...
Leto:
2020
Vir:
Medicinska fakulteta (UL MF)
Kratki znanstveni prispevek
Oznake:
circadian clock;genetics;PER2;PER3;sleep phase disorders;genotyping;
Delayed sleep phase disorder and advanced sleep phase disorder cause disruption of the circadian clock and present with extreme morning/evening chronotype with unclear role of the genetic etiology, especially for delayed sleep phase disorder. To assess if genotyping can aid in clinical diagnosis, we ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
hepatocellular carcinoma;meta-analysis;genome-scale metabolic modeling;
Hepatocellular carcinoma (HCC) is a major health problem around the world. The management of this disease is complicated by the lack of noninvasive diagnostic tools and the few treatment options available. Better clinical outcomes can be achieved if HCC is detected early, but unfortunately, clinical ...
Leto:
2023
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
DNA genomic ration;plasma electrochemical reduction;coupled plasmonic nanogold;DNA Raman fingerprints;
It is shown that surface-enhanced Raman spectroscopy (SERS) can identify bacteria based on their genomic DNA composition, acting as a “sample-distinguishing marker”. Successful spectral differentiation of bacterial species was accomplished with nanogold aggregates synthesized through single-step pla ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
branchiootorenal syndrome;chronic kidney disease;modifier genes;patient-derived fibroblasts;phenotypic heterogeneity;
Background Branchiootorenal (BOR) syndrome is an autosomal dominant disorder caused by pathogenic EYA1 variants and clinically characterized by auricular malformations with hearing loss, branchial arch anomalies, and congenital anomalies of the kidney and urinary tract (CAKUT). BOR phenotypes are hi ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)
Radka Symonová,
Tomáš Jůza,
Million Tesfaye,
Marek Brabec,
Daniel Bartoň,
Petr Blabolil,
Vladislav Draštík,
Luboš Kočvara,
Milan Muška,
Marie Prchalová,
Cene Skubic
Izvirni znanstveni članek
Oznake:
(Sander (Stizostedion) lucioperca);brain transcriptome;cannibalism;developmental plasticity;heterochrony;snoRNA;
Pikeperch (Sander Lucioperca) belongs to main predatory fish species in freshwater bodies throughout Europe playing the key role by reducing planktivorous fish abundance. Two size classes of the young-of-the-year (YOY) pikeperch are known in Europe and North America. Our long-term fish survey elucid ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
biosinteza holesterola;hepatocelularni karcinom;spolni dimorfizem;cholesterol biosynthesis;hepatocellular carcinoma;sex dimorphism;
While the role of cholesterol in liver carcinogenesis remains controversial, hepatocellular carcinoma generally prevails in males. Herein, we uncover pathways of female-prevalent progression to hepatocellular carcinoma due to chronic repression of cholesterogenic lanosterol 14[alpha]-demethylase (CY ...
Leto:
2020
Vir:
Medicinska fakulteta (UL MF)
Eva Kočar,
Sonja Katz,
Žiga Pušnik,
Petra Bogovič,
Gabriele Turel,
Cene Skubic,
Tadeja Režen,
Franc Strle,
Vitor A. P. Martins dos Santos,
Miha Mraz,
Miha Moškon,
Miha Moškon,
Damjana Rozman,
Damjana Rozman
Izvirni znanstveni članek
Oznake:
COVID-19;holesterol;biosinteza;steroli;lipidi;bioinformatika;ocenjevanje v zdravstveni tehnologiji;
With COVID-19 becoming endemic, there is a continuing need to find biomarkers characterizing the disease and aiding in patient stratification. We studied the relation between COVID-19 and cholesterol biosynthesis by comparing 10 intermediates of cholesterol biosynthesis during the hospitalization of ...
Leto:
2023
Vir:
Medicinska fakulteta (UL MF)