Št. zadetkov: 14
Pregledni znanstveni članek
Oznake:
Venoms are complex mixtures of different molecules and ions. Among them, bioactive peptides have been found to affect cancer hallmarks, such as cell proliferation, cell invasion, cell migration, and can also modulate the immune response of normal and cancer-bearing organisms. In this article, we rev ...
Leto:
2022
Vir:
Nacionalni inštitut za biologijo (NIB)
Pregledni znanstveni članek
Oznake:
carcinomas;cancer stem cellsInvasion;proteases;tumour microenvironment;
Epithelial-to-mesenchymal transition (EMT) is an essential molecular and cellular process that is part of normal embryogenesis and wound healing, and also has a ubiquitous role in various types of carcinoma and glioblastoma. EMT is activated and regulated by specific microenvironmental endogenous tr ...
Leto:
2020
Vir:
Nacionalni inštitut za biologijo (NIB)
Druge monografije in druga zaključena dela
Oznake:
genetska toksikologija;citogenetika;raziskave raka;biologija raka;zborniki;znanstvena posvetovanja;
CutCancer Final Conference 2025
Leto:
2025
Vir:
Nacionalni inštitut za biologijo (NIB)
Objavljeni povzetek znanstvenega prispevka na konferenci
Oznake:
glioblastom;organoidi;odpornost;možganski rak;možganski tumor;onkologija;
Organoidi glioblastoma kot model za preučevanje odpornosti na terapijo
Leto:
2022
Vir:
Nacionalni inštitut za biologijo (NIB)
Objavljeni povzetek znanstvenega prispevka na konferenci
Oznake:
glioblastom;organoidi;standardna terapija;model ex vivo;biologija raka;
Organoidi glioblastoma razkrivajo odpornost na standardno terapijo
Leto:
2023
Vir:
Nacionalni inštitut za biologijo (NIB)
Tamara Lah Turnšek,
Bernarda Majc,
Metka Novak,
Ajda Sušnik,
Barbara Breznik,
Andrej Porčnik,
Roman Bošnjak,
Aleksander Sadikov,
Marta Malavolta,
Selma Halilčević,
Jernej Mlakar,
Roby Zomer
Izvirni znanstveni članek
Oznake:
glioblastoma;glioma;cannabigerol;cannabidiol;cannabinoid receptors;stem cells;
Glioblastoma (GBM) is one of the most aggressive cancers, comprising 60–70% of all gliomas. The large G-protein-coupled receptor family includes cannabinoid receptors CB1, CB2, GPR55, and non-specific ion receptor protein transporters TRPs. First, we found up-regulated CNR1, GPR55, and TRPV1 express ...
Leto:
2022
Vir:
Nacionalni inštitut za biologijo (NIB)
Andrej Porčnik,
Metka Novak,
Barbara Breznik,
Bernarda Majc,
Barbara Hrastar,
Neja Zupanec,
Alja Zottel,
Ivana Jovchevska,
Miloš Vittori,
Ana Rotter,
Radovan Komel,
Tamara Lah Turnšek
Izvirni znanstveni članek
Oznake:
glioblastom;TRIM28;nanoprotitelesa;
Glioblastoma (GB), is the most common and aggressive malignant primary brain tumour in adults. Intra- and inter-tumour heterogeneity, infiltrative GB cell invasion and presence of therapy-resistant GB stem cells (GSCs) represent major obstacles to favourable prognosis and poor therapy response. Iden ...
Leto:
2021
Vir:
Nacionalni inštitut za biologijo (NIB)
Barbara Breznik,
Bernarda Majc,
Anamarija Habič,
Urška Ušeničnik,
Andrej Porčnik,
Roman Bošnjak,
Jernej Mlakar,
Marija Skoblar Vidmar,
Tanja Dolinšek,
Maja Čemažar,
Tamara Lah Turnšek,
Metka Novak
Objavljeni znanstveni prispevek na konferenci (vabljeno predavanje)
Oznake:
glioblastom;mikrookolje;organoidi;možganski rak;možganski tumor;onkologija;
Glioblastom je najpogostejši možganski tumor pri odraslih z zelo slabo prognozo preživetja bolnikov. Ta je posledica odpornosti glioblastoma na standardno zdravljenje, ki vključuje radioterapijo in kemoterapijo. Z namenom načrtovanja učinkovitejših pristopov zdravljenja preučujemo biološke mehanizme ...
Leto:
2022
Vir:
Nacionalni inštitut za biologijo (NIB)
Metka Novak,
Miha Koprivnikar Krajnc,
Barbara Hrastar,
Barbara Breznik,
Bernarda Majc,
Mateja Mlinar,
Ana Rotter,
Andrej Porčnik,
Jernej Mlakar,
Katja Stare,
Richard G. Pestell,
Tamara Lah Turnšek
Izvirni znanstveni članek
Oznake:
glioblastom;kemokini;tumorsko mikrookolje;invazija;CCL5;CCR5;chemokines;glioblastoma;invasion;maraviroc;mesenchymal stem cells;
Abstract
The chemokine CCL5/RANTES is a versatile inflammatory mediator, which interacts with the receptor CCR5, promoting cancer cell interactions within the tumor microenvironment. Glioblastoma is a highly invasive tumor, in which CCL5 expression correlates with shorter patient survival. Using im ...
Leto:
2020
Vir:
Nacionalni inštitut za biologijo (NIB)
Barbara Breznik,
Meng-Wei Ko,
Christopher Tse,
Po-Chun Chen,
Emanuela Senjor,
Bernarda Majc,
Anamarija Habič,
Nicolas Angelillis,
Metka Novak,
Vera Župunski,
Jernej Mlakar,
David Nathanson,
Anahid Jewett
Izvirni znanstveni članek
Oznake:
glioblastom;naravne celice ubijalke;translacijska onkologija;glioblastoma;natural killer cells;translational oncology;
Glioblastomas remain the most lethal primary brain tumors. Natural killer (NK) cell-based therapy is a promising immunotherapeutic strategy in the treatment of glioblastomas, since these cells can select and lyse therapy-resistant glioblastoma stem-like cells (GSLCs). Immunotherapy with super-charge ...
Leto:
2022
Vir:
Nacionalni inštitut za biologijo (NIB)