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Targeting steroid-metabolizing enzymes with 15β-substituted estrone analogues
Vivien Resch, Marija Gjorgoska, Eva Hafner, Ildikó Bacsa, Benjamin Kovács, Tomaž Büdefeld, Attila Hunyadi, Ildikó Huliák, Mónika Kiricsi, Gábor Paragi, Tea Lanišnik-Rižner, Tea Lanišnik-Rižner
Izvirni znanstveni članek
Oznake: 17β-HSD1 enzyme;AKR1C1–3 enzymes;antiproliferative;chemoresistance;fluorescent labeling;inhibitor;
Background/objectives: Aldo-keto reductase isoforms AKR1C1-3 and 17β-hydroxysteroid dehydrogenase 1 and 2 (17β-HSD1 and 17β-HSD2) are key enzymes in steroid metabolism and validated targets in hormone-dependent cancers. Methods: In this study, Δ15- and 15β-substituted estrone derivatives were evalua ...
Leto: 2026 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 1
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