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Št. zadetkov: 4
Physics-based surface patch analysis for prediction of hydrophobic contribution to viscosity of mAbs
Benjamin Knez, Miha Ravnik, Mitja Zidar
Izvirni znanstveni članek
Oznake: hidrofobnost;viskoznost;biofarmacevtiki;monoklonska protitelesa;hydrophobicity;viscosity;biopharmaceuticals;monoclonal antibodies;
The viscosity of monoclonal antibody solutions is critical in their biopharmaceutical application, as it directly influences the ease of subcutaneous injection. Although many descriptors have been developed to enable the in silico prediction of viscosity, they are typically based on electrostatic pr ...
Leto: 2026 Vir: Fakulteta za matematiko in fiziko (UL FMF)
Prediction of aggregation in monoclonal antibodies from molecular surface curvature
Benjamin Knez, Lara Erzin, Žiga Kos, Drago Kuzman, Miha Ravnik
Izvirni znanstveni članek
Oznake: biofizika;proteini;monoklonska protitelesa;agregacija;biophysics;biopharmaceutics;proteins;monoclonal antibidies;aggregation;
Protein aggregation is one of the key challenges in the biopharmaceutical industry as its control is crucial in achieving long-term stability and efficacy of biopharmaceuticals. Attempts have been made to develop regression models for predicting the aggregation of monoclonal antibodies in solution u ...
Leto: 2025 Vir: Fakulteta za matematiko in fiziko (UL FMF)
ǂA ǂmultifaceted approach to understanding protein-buffer interactions in biopharmaceuticals
Blaž Lebar, Maria Toplishek, Boštjan Japelj, Ernest Šprager, Rok Podlipec, Tilen Knaflič, Iztok Urbančič, Benjamin Knez, Mitja Zidar, Jure Cerar, Janez Mravljak, Aleš Žula, Denis Arčon, Janez Plavec, Stane Pajk
Izvirni znanstveni članek
Oznake: biokemija;jedrska magnetna resonanca;NMR;molekulska dinamika;
Leto: 2024 Vir: Kemijski inštitut (KI)
ǂA ǂdeep dive into spin-labeled polysorbate’s interaction with therapeutic antibody using 2D NMR, EPR and MD simulations
Blaž Lebar, Maria Toplishek, Boštjan Japelj, Ernest Šprager, Rok Podlipec, Tilen Knaflič, Iztok Urbančič, Benjamin Knez, Mitja Zidar, Jure Cerar, Janez Mravljak, Aleš Žula, Denis Arčon, Janez Plavec, Stane Pajk
Izvirni znanstveni članek
Oznake: monoklonsko protitelo;interakcija polisorbat;jedrska magnetna resonanca;elektronska paramagnetna resonanca;molekularna dinamika;monoclonal antibody;interaction polysorbate;nuclear magnetic resonance;electron paramagnetic resonance;molecular dynamics;
Polysorbates (PS) are widely used surfactants in biopharmaceutical formulations playing a crucial role in protecting proteins against mechanical stress and interface-induced damage. However, their susceptibility to degradation can compromise their function and lead to particle formation. Recent stud ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 4
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