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Urinary extracellular vesicles (uEVs) have emerged as a promising and versatile source of non-invasive biomarkers for kidney allograft monitoring. This review summarizes current evidence on uEV-derived biomarkers, including proteins, gene expression signatures, microRNAs, and extracellular vesicle-a ...

Urine is commonly used for clinical diagnosis and biomedical research. The discovery of extracellular vesicles (EV) in urine opened a new fast-growing scientific field. In the last decade urinary extracellular vesicles (uEVs) were shown to mirror molecular pro- cesses as well as physiological and pa ...

Despite remarkable interest in the biomarker potential of urinary extracellular vesicles (uEVs) and the identification of numerous promising candidates, their clinical translation still presents multiple challenges. The opportunities for successful translation are obvious, yet the main roadblocks on ...