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Št. zadetkov: 3
Development of the fish invitrome for animal-free environmental risk assessment of chemicals
Marion Revel, Ksenia J Groh, Jessica Bertoli, Mihai-Ovidiu Degeratu, Melanie Fischer, Stephan Fischer, Jarno Hoekman, Barbara Jozef, Roman Li, Anže Županič
Izvirni znanstveni članek
Oznake: sistemska toksikologija;alternative eksperimentom na živalih;mavrična postrv;ekotoksikologija;new approach methodologies (NAMs);rainbow trout cell lines;toxicity testing;socio-technical approach;co-design with stakeholders;
Given the need to reduce animal testing for environmental risk assessment, we aim to develop a fish invitrome, an alternative fish modular framework capable of predicting chemical toxicity in fish without the use of animals. The central module of the framework is the validated RTgill-W1 cell line as ...
Leto: 2025 Vir: Nacionalni inštitut za biologijo (NIB)
ǂA ǂnew fibrillization mechanism of ß-lactoglobulin in glycine solutions
Matej Jaklin, Jozef Hritz, Barbara Hribar
Izvirni znanstveni članek
Oznake: ß-laktoglobulin;fibrilizacijski mehanizem;pufer specifični efekt;sferoidni oligomeri;ß-lactoglobulin;fibrillization mechanism;buffer specific effects;spheroid oligomers;
Even though amyloid aggregates were discovered many years ago the mechanism of their formation is still a mystery. Because of their connection to many of untreatable neurodegenerative diseases the motivation for finding a common aggregation path is high. We report a new high heat induced fibrillizat ...
Leto: 2022 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
ǂThe ǂeffect of cosolutes on amyloid fibril formation in the case of [beta]-lactoglobulin
Matej Jaklin, Barbara Hribar, Tomaž Urbič, Miha Pavšič, Jozef Hritz
Doktorska disertacija
Oznake: beta-lactoglobulin;amyloid fibrils;polymorphism;co-solutes;phase separation;amphiphilicity;protein vesicles;thiol group;microscopy;aggregation;photonic crystals;
Protein aggregation, particularly amyloid fibrils, poses challenges for biopharmaceutical production and contributes to incurable diseases such as neurodegeneration, transthyretin amyloidosis, and type II diabetes. Amyloid fibrils are highly stable aggregates composed of cross-β structures. They hav ...
Leto: 2025 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Št. zadetkov: 3
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