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Št. zadetkov: 28
Klinično farmakogenetski modeli za bolniku prilagojeno zdravljenje revmatoidnega artritisa
Barbara Jenko, Vita Dolžan, Sonja Praprotnik
Doktorska disertacija
Oznake: genetski polimorfizem;zdravljenje;metotreksat;leflunomid;interna medicina;genetika, medicinska;zdravljenje z zdravili;
Klinično farmakogenetski modeli za bolniku prilagojeno zdravljenje revmatoidnega artritisa
Leto: 2016 Vir: Medicinska fakulteta (UL MF)
Clinical and clinical-pharmacogenetic models for prediction of the most common psychiatric complications due to dopamingeric treatment in Parkinson's disease
Sara Redenšek, Barbara Jenko, Maja Trošt, Vita Dolžan
Izvirni znanstveni članek
Oznake: Parkinson's disease;polymorphism;pharmacogenetics;
Background: The most common psychiatric complications due to dopaminergic treatment in Parkinson's disease are visual hallucinations and impulse control disorders. Their development depends on clinical and genetic factors.Methods: We evaluated the simultaneous effect of 16 clinical and 34 genetic va ...
Leto: 2020 Vir: Medicinska fakulteta (UL MF)
Priprava usmerjene bakteriofagne knjižnice cikličnih peptidov in afinitetni izbor ligandov človeških imunoglobulinov G
Klemen Gnidovec, Tomaž Bratkovič, Barbara Jenko Bizjan
Magistrsko delo
Oznake: peptidna knjižnica;predstavitev na bakteriofagu;ciklični peptidi;elektroporacija;imunoglobulini G;
Monoklonska protitelesa so zaradi velike specifičnosti in afinitete vezave pomemben del terapije in diagnostike številnih bolezni. Proizvajamo jih s tehnologijo rekombinantne DNA v sesalskih celicah, ključna pri njihovi izolaciji iz fermentacijske brozge pa je afinitetna kromatografija. Trenutno n ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Focused peptide library screening as a route to a superior affinity ligand for antibody purification
Krištof Bozovičar, Barbara Jenko, Anže Meden, Jernej Kovač, Tomaž Bratkovič
Izvirni znanstveni članek
Oznake: peptidne knjižnice;ELISA;
Affinity chromatography is the linchpin of antibody downstream processing and typically relies on bacterial immunoglobulin (Ig)-binding proteins, epitomized by staphylococcal protein A-based ligands. However, such afnity ligands are fairly costly and sufer from chemical instability, leading to ligan ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Opredelitev sprememb v genu in psevdogenih PKD1 pri bolnikih z avtosomno dominantno policistično boleznijo ledvic
Lara Snoj, Katarina Trebušak Podkrajšek, Barbara Jenko Bizjan
Magistrsko delo
Oznake: Avtosomna dominantna policistična bolezen ledvic;verižna reakcija s polimerazo za pomnoževanje dolgih odsekov;sekvenciranje naslednje generacije;občutljivost;psevdogeni.;
Avtosomna dominantna policistična bolezen ledvic je ena izmed najpogostejših življenje ogrožajočih genetskih motenj. Povzročajo jo spremembe v genih PKD1 in PKD2, ki sledijo avtosomno dominantnemu načinu dedovanja. Policistin-1 in policistin-2, proteinska produkta genov PKD1 in PKD2, sta integralna ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Clinical pharmacogenetic models of treatment response to methotrexate monotherapy in Slovenian and Serbian rheumatoid arthritis patients
Barbara Jenko, Matija Tomšič, Biljana Jekić, Vera Milić, Vita Dolžan, Sonja Praprotnik
Izvirni znanstveni članek
Oznake: rheumatoid arthritis;methotrexate;pharmacogenetics;polymorphism;predictive model;
Objectives: Methotrexate (MTX) is the first line treatment for rheumatoid arthritis (RA), but nevertheless 30% of patients experience MTX inefficacy. Our aim was to develop a clinical pharmacogenetic model to predict which RA patients will not respond to MTX monotherapy. We also assessed whether thi ...
Leto: 2018 Vir: Medicinska fakulteta (UL MF)
Exploring early DNA methylation alterations in type 1 diabetes
Barbara Čugalj Kern, Jernej Kovač, Robert Šket, Barbara Jenko, Julia Galhardo, Tadej Battelino, Nataša Bratina, Klemen Dovč
Izvirni znanstveni članek
Oznake: type 1 diabetes;glycemic control;DNA methylation;diabetes-related complications;long-read sequencing;
Background: Prolonged hyperglycemia causes diabetes-related micro- and macrovascular complications, which combined represent a significant burden for individuals living with diabetes. The growing scope of evidence indicates that hyperglycemia affects the development of vascular complications through ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
Detection of metabolic syndrome burden in healthy young adults may enable timely introduction of disease prevention
Anja Šoštarič, Barbara Jenko, Nada Rotovnik-Kozjek, Darja Ovijač, Dušan Šuput, Irina Milisav, Vita Dolžan
Izvirni znanstveni članek
Oznake: metabolic syndrome;young adults;anthropometry;nutrition;exercise;
Introduction: Metabolic syndrome and associated diseases are a  global health problem. Detection of early metabolic modifications that may lead to metabolic syndrome would enable timely introduction of preventive lifestyle modifications. Material and methods: In total 103 young, healthy adults were ...
Leto: 2019 Vir: Medicinska fakulteta (UL MF)
Milestone M27
Luka Ausec, Barbara Jenko, Janez Kokošar, Amrita Roy Choudhury, Miha Štajdohar, Kristina Gruden, Maja Križnik, Marko Petek, Živa Ramšak
Končno poročilo o rezultatih raziskav
Oznake: podatki;sistemska biologija;bolezni rastlin;
We present the technical report regarding the implementation of the Genialis Platform at the National Institute of Biology (NIB) within the project Hyp (J4-7636).
Leto: 2018 Vir: Nacionalni inštitut za biologijo (NIB)
Integrating genetic insights, technological advancements, screening, and personalized pharmacological interventions in childhood obesity
Robert Šket, Robert Šket, Barbara Slapnik, Primož Kotnik, Klementina Črepinšek, Barbara Čugalj Kern, Tine Tesovnik, Barbara Jenko, Blaž Vrhovšek, Žiga Iztok Remec, Maruša Debeljak, Tadej Battelino, Jernej Kovač
Pregledni znanstveni članek
Oznake: hemophilia;wearable;Florio HAEMO;adherence;patient satisfaction;
Childhood obesity is a significant global health challenge with rising prevalence over the past 50 years, affecting both immediate and long-term health outcomes. The increase in prevalence from 0.7% to 5.6% in girls and 0.9% to 7.8% in boys highlights the urgency of addressing this epidemic. By 2025 ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 28
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