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Št. zadetkov: 3
Application of antiSMASH tool for identification and analysis of type II polyketide gene clusters
Vladimir Grujić, Hrvoje Petković, Antonio Starcevic, Blaž Stres
Magistrsko delo
Oznake: actinomycetes;biosynthetic gene cluster;biotechnology;type II polyketide synthase;
Actinomycetes are one of the most economically and biotechnologically valuable prokaryotes considering that they produce wide range of bioactive secondary metabolites, such as antibacterials, antitumor agents and immunosuppressive agents. Aromatic polyketides are produced by type II polyketide synth ...
Leto: 2021 Vir: Biotehniška fakulteta (UL BF)
Modulating complex secondary metabolism in Streptomyces rimosus by targeted genome engineering
Martina Avbelj, Lucija Slemc, Alen Pšeničnik, Špela Zver, Anastasija Lazova, Kristina Mervič, Khan Mohammad Sarim, Maja Paš, Antonio Starcevic, Martin Šala, Miha Tome, Dušica Vujaklija, Hrvoje Petković
Izvirni znanstveni članek
Oznake: antibiotiki;oksitetraciklin;Streptomyces rimosus;biosinteza;gruča biosinteznih genov;sekundarni metaboliti;biosynthetic gene cluster;oxytetracycline;rimocidin;gene regulation;genome reduction;
Research background. Numerous biosynthetic gene clusters (BGCs) encoding unknown structures have been uncovered in the genomes of diverse microorganisms, representing a potentially rich source of novel natural products. However, the majority of the BGCs identified do not seem to be active, since we ...
Leto: 2026 Vir: Biotehniška fakulteta (UL BF)
Oxytetracycline hyper-production through targeted genome reduction of Streptomyces rimosus
Alen Pšeničnik, Lucija Slemc, Martina Avbelj, Miha Tome, Martin Šala, Paul R. Herron, Maksym Shmatkov, Marko Petek, Špela Baebler, Peter Mrak, Daslav Hranueli, Antonio Starcevic, Iain S. Hunter, Hrvoje Petković
Izvirni znanstveni članek
Oznake: aktinomicete;Streptomyces rimosus;tetraciklini;biosinteza;genome reduction;antibiotic biosynthesis;oxytetracycline;cryptic metabolites;
Most biosynthetic gene clusters (BGC) encoding the synthesis of impor­tant microbial secondary metabolites, such as antibiotics, are either silent or poorly expressed; therefore, to ensure a strong pipeline of novel antibiotics, there is a need to develop rapid and efficient strain development appro ...
Leto: 2024 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Št. zadetkov: 3
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