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Št. zadetkov: 4
Vpliv zaviralcev proprotein subtilizin/keksin pretvarjajočega encima 9 (PCSK9) na lipidne subfrakcije, vnetje in arterijsko steno pri bolnikih z zgodnjo koronarno boleznijo
Andreja Rehberger Likozar, Miran Šebeštjen
Doktorska disertacija
Oznake: lipoprotein (a);endotelijska funkcija;holesterol nizke gostote;koronarna bolezen;ateroskleroza;hemostaza;zaviralci PCSK9;enonukleotidni polimorfizmi v genu LPA rs10455872 in rs3798220;KIV2 aminokislinske ponovitve;
Lipoprotein(a) (Lp(a)) je pomemben dejavnik tveganja za koronarno bolezen ter prognostični napovednik pri bolnikih po akutnem koronarnem sindromu (AKS), ne glede na vrednosti holesterola nizke gostote (LDL, ang. »low density lipoprotein cholesterol«). Izsledki novejših raziskav so pokazali, da so za ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
LPA genotypes and haplotypes are associated with lipoprotein(a) levels but not arterial wall properties in stable post-coronary event patients with very high lipoprotein(a) levels
Andreja Rehberger Likozar, Aleš Blinc, Katarina Trebušak Podkrajšek, Miran Šebeštjen
Izvirni znanstveni članek
Oznake: coronary artery disease;LPA genotypes;haplotypes;
Lipoprotein(a) [Lp(a)] levels are an independent risk factor for coronary artery disease (CAD). Two single-nucleotide polymorphisms (rs10455872, rs3798220) and number of KIV-2 repeats in the gene encoding Lp(a) (LPA) are associated with Lp(a) and CAD. Our aim was to investigate whether in patients w ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Effect of PCSK9 inhibitors on regulators of lipoprotein homeostasis, inflammation and coagulation
Patricija Lunar, Hana Meglič, Mateja Vehar, Sabina Ugovšek, Andreja Rehberger Likozar, Miran Šebeštjen, Janja Zupan
Izvirni znanstveni članek
Oznake: PCSK9 inhibitors;lipid regulators;inflammation;coagulation;coronary artery disease;
Background: PCSK9 inhibitors (PCSK9i) represent a newer form of atherosclerosis treatment. Inflammation and haemostasis are key processes in the development of atherosclerosis. In this study, we investigated the influence of therapy with PCSK9i in patients with coronary artery disease (CAD) on regul ...
Leto: 2025 Vir: Medicinska fakulteta (UL MF)
Treatment with PCSK9 inhibitors influences microRNAs expression and changes of arterial wall properties
Andreja Rehberger Likozar, Tina Levstek, Tina Karun, Katarina Trebušak Podkrajšek, Janja Zupan, Miran Šebeštjen
Izvirni znanstveni članek
Oznake: miRNA;endothelial function;PCSK9 inhibitors;myocardial infarction;low-density lipoprotein cholesterol;
Background: MicroRNAs (miRNAs) are involved in the synthesis of proprotein convertase subtilisin–kexin type 9 (PCSK9), one of the regulators of low-density lipoprotein cholesterol (LDL-C) metabolism, and are directly involved in the atherosclerotic process. The aim of this study was to verify whethe ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 4
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