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Št. zadetkov: 2
Mechanistic insights into AAV capsid–stationary phase interactions governing native stability and chromatographic separation using AAV8 as a model system
Timotej Žvanut, Mitja Martelanc, Aleš Štrancar, Andreja Gramc-Livk
Izvirni znanstveni članek
Oznake: adeno-associated virus;empty/partially filled/full;separation efficiency;capsid stability;weak anion exchanger;interactions;in-line buffer exchange;
Background/Objectives: Adeno-associated viruses (AAVs) are widely used gene therapy vectors; yet their physicochemical stability and chromatographic behavior are highly sensitive to the solution conditions they are in. Effective separation of full (F), empty (E), and partially filled (P) capsids—mos ...
Leto: 2026 Vir: Univerza v Novi Gorici (UNG)
ǂA ǂtwo-dimensional hyphenated ion-exchange chromatographic platform for simultaneous assessment of AAV8 capsids and impurity fingerprinting in upstream processes
Timotej Žvanut, Tjaša Kašček, Lara Vogrinčič, Petra Dekleva, Sandra Hasić, Anže Martinčič Celjar, Ivana Petrović Koshmak, Blaž Goričar, Mitja Martelanc, Aleš Štrancar, Andreja Gramc-Livk
Izvirni znanstveni članek
Oznake: complex samples;upstream process monitoring;two-dimensional hyphenated liquid chromatography;Adeno-associated virus;full capsid content;
Reliable monitoring of full (F) versus empty (E) adeno-associated virus (AAV) capsids, along with impurity fingerprinting, is essential for optimising upstream processes (USPs). Conventional analytical workflows for USP monitoring, including PCR-ELISA and one-dimensional (1D) liquid chromatography ( ...
Leto: 2026 Vir: Univerza v Novi Gorici (UNG)
Št. zadetkov: 2
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