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Št. zadetkov: 6
Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells
Milica Perišić, Jerica Sabotič, Anahid Jewett, Janko Kos
Pregledni znanstveni članek
Oznake: katepsini;cisteini;citotoksičnost;citotoksične T celice;naravne celice ubijalke;
Cysteine cathepsins are lysosomal peptidases involved at different levels in the processes of the innate and adaptive immune responses. Some, such as cathepsins B, L, and H are expressed constitutively in most immune cells. In cells of innate immunity they play a role in cell adhesion and phagocytos ...
Leto: 2014 Vir: Repozitorij Univerze v Ljubljani (RUL)
Synthetic cannabinoid WIN 55,212–2 inhibits growth and induces cell death of oral and pancreatic stem-like/poorly differentiated tumor cells
Meng-Wei Ko, Barbara Breznik, Emanuela Senjor, Anahid Jewett
Izvirni znanstveni članek
Oznake: rakave matične celice;kanabinoidi;celična smrt;biologija raka;genetska toksikologija;cancer stem cells;cannabinoids;cell death;cancer biology;genetic toxicology;
We report here that synthetic cannabinoid WIN 55,212–2 inhibits tumor cell proliferation and induces cell death of oral and pancreatic tumor cells, and the effect is much more pronounced on stem-like/poorly differentiated OSCSCs and MP2 cells when compared to well-differentiated OSCCs, and PL-12 tum ...
Leto: 2022 Vir: Nacionalni inštitut za biologijo (NIB)
Cystatin F affects natural killer cell cytotoxicity
Milica Perišić, Jerica Sabotič, Urban Švajger, Anahid Jewett, Janko Kos
Izvirni znanstveni članek
Oznake:
Leto: 2017 Vir: Institut Jožef Stefan (IJS)
Osteoclast-expanded supercharged NK cells perform superior antitumour effector functions
Meng-Wei Ko, Ao Mei, Emanuela Senjor, Milica Perišić, Janko Kos, Anahid Jewett
Izvirni znanstveni članek
Oznake: protitumorska funkcija;antitumour function;
Objective. Natural killer (NK) cells are the largest innate lymphocyte subset with potent antitumour and antiviral functions. However, clinical utilisation of human NK cells is hampered due to a lack of reliable methods to augment their antitumour potential. We demonstrated technology in which human ...
Leto: 2025 Vir: Institut Jožef Stefan (IJS)
Different glycosylation profiles of cystatin F alter the cytotoxic potential of natural killer cells
Emanuela Senjor, Martina Pirro, Urban Švajger, Mateja Prunk, Jerica Sabotič, Anahid Jewett, Paul J. Hensbergen, Milica Perišić, Janko Kos
Izvirni znanstveni članek
Oznake: cystatin F;immunosuppression;NK cells;N-Glycosylation;
Cystatin F, a cysteine peptidase inhibitor, is a potent modulator of NK cytotoxicity. By inhibiting granule-mediated cytotoxicity pathway, cystatin F induces formation of non-functional NK cell stage, called split-anergy. We show that N-glycosylation determines the localization and cellular function ...
Leto: 2024 Vir: Repozitorij Univerze v Ljubljani (RUL)
Infiltrating natural killer cells bind, lyse and increase chemotherapy efficacy in glioblastoma stem-like tumorospheres
Barbara Breznik, Meng-Wei Ko, Christopher Tse, Po-Chun Chen, Emanuela Senjor, Bernarda Majc, Anamarija Habič, Nicolas Angelillis, Metka Novak, Vera Župunski, Jernej Mlakar, David Nathanson, Anahid Jewett
Izvirni znanstveni članek
Oznake: glioblastom;naravne celice ubijalke;translacijska onkologija;glioblastoma;natural killer cells;translational oncology;
Glioblastomas remain the most lethal primary brain tumors. Natural killer (NK) cell-based therapy is a promising immunotherapeutic strategy in the treatment of glioblastomas, since these cells can select and lyse therapy-resistant glioblastoma stem-like cells (GSLCs). Immunotherapy with super-charge ...
Leto: 2022 Vir: Nacionalni inštitut za biologijo (NIB)
Št. zadetkov: 6
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