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Št. zadetkov: 3
Borrelia-specific antibody profiles and complement deposition in joint fluid distinguish antibiotic-refractory from -responsive Lyme arthritis
Kathryn A. Bowman, Christine D. Wiggins, Elizabeth DeRiso, Steffan Paul, Klemen Strle, John A. Branda, Allen C. Steere, Douglas A. Lauffenburger, Galit Alter
Izvirni znanstveni članek
Oznake: borelia;Lyme arthritis;antibiotic;
Lyme arthritis, caused by the spirochete Borrelia burgdorferi, is the most common feature of late disseminated Lyme disease in the United States. While most Lyme arthritis resolves with antibiotics, termed “antibiotic-responsive”, some individuals develop progressive synovitis despite antibiotic the ...
Leto: 2024 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Toll-like receptor 1 polymorphism is associated with impaired immune tolerance, dysregulated inflammatory responses to Borrelia burgdorferi, and heightened risk of post-infectious Lyme arthritis
Morgan A. Williams, Sergio A. Hernández, Sheila Arvikar, Katherine B. Sulka, Franc Strle, Christopher C. Wells, Tanja Petnicki-Ocwieja, Allen C. Steere, Klemen Strle
Izvirni znanstveni članek
Oznake: Lyme disease;Borrelia burgdorferi;toll-like receptors;innate immune tolerance;inflammation;Lyme arthritis;innate immunology;
Introduction: Clinical presentation of Lyme disease is largely due to host immune response to infection. Previously, we identified a variant (1805GG) in the TLR1 gene, a key immune sensor for Borrelia burgdorferi, which was associated with excessive inflammation and severe disease. Herein we examine ...
Leto: 2025 Vir: Repozitorij Univerze v Ljubljani (RUL)
HLA-DR–expressing fibroblast-like synoviocytes are inducible antigen presenting cells that present autoantigens in Lyme arthritis
Joseph R. Rouse, Rebecca Danner, Amanda Wahhab, Michaela Pereckas, Christine Nguyen, Mecaila E. McClune, Allen C. Steere, Klemen Strle, Brandon L. Jutras, Robert B. Lochhead
Izvirni znanstveni članek
Oznake: Lyme arthritis;autoimmune diseases;infectious disease;
Objective: HLA-DR–expressing fibroblast-like synoviocytes (FLS) are a prominent cell type in synovial tissue in chronic inflammatory forms of arthritis. FLS-derived extracellular matrix (ECM) proteins, including fibronectin-1 (FN1), contain immunogenic CD4+ T cell epitopes in patients with postinfec ...
Leto: 2024 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Št. zadetkov: 3
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