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Št. zadetkov: 2
N-propargylpyrrolidine-based butyrylcholinesterase and monoamine oxidase inhibitors
Urban Košak, Damijan Knez, Anja Hafner, Selena Horvat, Simon Žakelj, Alexandre Igert, Jose Dias, Florian Nachon, Xavier Brazzolotto, Stanislav Gobec
Izvirni znanstveni članek
Oznake: butyrylcholinesterase;acetylcholinesterase;monoamine oxidase;monoamine oxidase A;monoamine oxidase B;enzyme inhibitors;pyrrolidines;
Butyrylcholinesterase (BChE) inhibitors are or could be used for the treatment of Alzheimer's disease, canine cognitive dysfunction, depression, multiple sclerosis, heroin abuse and metabolic disorders. Monoamine oxidase (MAO) inhibitors are or could be used for the treatment of depression, anxiety, ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Structure-guided design of a brain-penetrant covalent inhibitor of human butyrylcholinesterase with in vivo procognitive efficacy
Peter Mastnak-Sokolov, Urban Košak, Anže Meden, Damijan Knez, Simon Žakelj, Selena Horvat, Anja Pišlar, Jakob Kljun, Alexandre Igert, Stanislav Gobec, Stanislav Gobec
Izvirni znanstveni članek
Oznake: butirilholinesteraza (BChE);bisnorcimserin;kinetična analiza;zdravljenje Alzheimerjeve bolezni;
Butyrylcholinesterase (BChE) has emerged as a validated therapeutic target for the management of Alzheimer’s disease symptoms, particularly in advanced stages when acetylcholinesterase activity declines. Despite the numerous BChE inhibitors reported, only the cymserine derivative bisnorcymserine has ...
Leto: 2026 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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