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Št. zadetkov: 2
Structural and proteomic analysis of the mouse cathepsin B-DARPin 4m3 complex reveals species-specific binding determinants
Miki Zarić, Livija Tušar, Lovro Kramer, Lovro Kramer, Olga Vasiljeva, Matej Novak, Francis Impens, Aleksandra Usenik, Kris Gevaert, Dušan Turk, Boris Turk
Izvirni znanstveni članek
Oznake: katepsin B;proteomika;zaviralci;cathepsin B;protein inhibitor;proteomics;
Cathepsin B (CatB) is a lysosomal cysteine protease that plays a major role in various pathologies and is therefore considered a valuable therapeutic target. To address species-specific inhibitor challenges, we characterized the selective binding of designed ankyrin repeat protein (DARPin) 4m3 towar ...
Leto: 2025 Vir: Institut Jožef Stefan (IJS)
ǂA ǂmini-TGA protein modulates gene expression through heterogeneous association with transcription factors
Špela Tomaž, Marko Petek, Tjaša Lukan, Karmen Pogačar, Katja Stare, Erica Teixeira Prates, Daniel A. Jacobson, Jan Zrimec, Gregor Bajc, Matej Butala, Maruša Pompe Novak, Ajda Taler-Verčič, Aleksandra Usenik, Dušan Turk, Anna Coll Rius, Kristina Gruden
Izvirni znanstveni članek
Oznake: proteini mini-TGA;rastlinski imunski odziv;transkripcijski faktorji TGA;virus krompirja Y;
TGA (TGACG-binding) transcription factors, which bind their target DNA through a conserved basic region leucine zipper (bZIP) domain, are vital regulators of gene expression in salicylic acid (SA)-mediated plant immunity. Here, we investigated the role of StTGA2.1, a potato (Solanum tuberosum) TGA l ...
Leto: 2022 Vir: Nacionalni inštitut za biologijo (NIB)
Št. zadetkov: 2
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