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Hepatic management of toxic sterols after acute deletion of Cyp51 from cholesterol synthesis
Tinkara Kreft, Kaja Blagotinšek Cokan, Cene Skubic, Tadeja Režen, Martina Perše, Karmen Wechtersbach, Nika Kojc, Jera Jeruc, Željko Debeljak, Marija Heffer, Madlen Matz-Soja, Damjana Rozman, Damjana Rozman
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Oznake: CYP51;cholesterol metabolism;crystals;cytochrome P450;lanosterol 14α-demethylase;lipid droplets;liver;mouse model;sterol;
Lanosterol 14α-demethylase (CYP51), a key enzyme in cholesterol synthesis, is essential for normal liver function. Reduced CYP51 activity leads to metabolism-associated liver disease and ultimately hepatocellular carcinoma, yet the hepatocellular processes most affected and their crosstalk with othe ...
Leto: 2026 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 1
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