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Št. zadetkov: 3
Genome-guided discovery of the first myxobacterial biarylitide Myxarylin reveals distinct C–N biaryl crosslinking in RiPP biosynthesis
Joachim J. Hug, Nicolas A. Frank, Christine Walt, Petra Šenica, Fabian Panter, Rolf Müller
Izvirni znanstveni članek
Oznake: myxobacteria;secondary metabolites;biarylitide;natural product discovery;RiPPs;genome mining;Myxarylin;
Abstract Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a structurally diverse group of natural products. They feature a wide range of intriguing post-translational modifications, as exemplified by the biarylitides. These are a family of cyclic tripeptides found i ...
Leto: 2021 Vir: Veterinarska fakulteta (UL VF)
Production of extracellular heterologous proteins in Streptomyces rimosus, producer of the antibiotic oxytetracycline
Andres Felipe Carrillo Rincon, Vasilka Magdevska, Luka Kranjc, Štefan Fujs, Rolf Müller, Hrvoje Petković
Izvirni znanstveni članek
Oznake: streptomicete;Streptomyces rimosus;sekundarni metaboliti;heterologni proteini;izražanje genov;encimi;fitaze;
Among the Streptomyces species, Streptomyces lividans has often been used for the production of heterologous proteins as it can secrete target proteins directly into the culture medium. Streptomyces rimosus, on the other hand, has for long been used at an industrial scale for oxytetracycline product ...
Leto: 2018 Vir: Biotehniška fakulteta (UL BF)
Amidochelocardin overcomes resistance mechanisms exerted on tetracyclines and natural chelocardin
Fabienne Hennessen, Marcus Miethke, Nestor Zaburannyi, Maria Loose, Tadeja Lukežič, Steffen Bernecker, Stephan Hüttel, Rolf Jansen, Judith Schmiedel, Moritz Fritzenwanker, Can Imirzalioglu, Jörg Vogel, Alexander J. Westermann, Thomas Hesterkamp, Marc Stadler, Florian Wagenlehner, Hrvoje Petković, Jennifer Herrmann, Rolf Müller
Izvirni znanstveni članek
Oznake: antibiotiki;poliketidi;tertaciklin;kelokardin;amidokelokardin;mehanizem delovanja;protimikrobna aktivnost;
The reassessment of known but neglected natural compounds is a vital strategy for providing novel lead structures urgently needed to overcome antimicrobial resistance. Scaffolds with resistance-breaking properties represent the most promising candidates for a successful translation into future thera ...
Leto: 2020 Vir: Biotehniška fakulteta (UL BF)
Št. zadetkov: 3
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